[HTML][HTML] The plasticity of pancreatic cancer stem cells: Implications in therapeutic resistance

K Patil, FB Khan, S Akhtar, A Ahmad… - Cancer and Metastasis …, 2021 - Springer
The ever-growing perception of cancer stem cells (CSCs) as a plastic state rather than a
hardwired defined entity has evolved our understanding of the functional and biological …

Bioactive components and molecular mechanisms of Salvia miltiorrhiza Bunge in promoting blood circulation to remove blood stasis

B Wei, C Sun, H Wan, Q Shou, B Han, M Sheng… - Journal of …, 2023 - Elsevier
Abstract Ethnopharmacological relevance Salvia miltiorrhiza Bunge (SM) is an outstanding
herbal medicine with various traditional effects, especially promoting blood circulation to …

[HTML][HTML] Tanshinone IIA protects human coronary artery endothelial cells from ferroptosis by activating the NRF2 pathway

L He, YY Liu, K Wang, C Li, W Zhang, ZZ Li… - Biochemical and …, 2021 - Elsevier
The pathogenesis of atherosclerosis is closely related to endothelial cell injury caused by
lipid peroxidation-induced ferroptosis. Tanshinone IIA (TSA) protects endothelial tissues …

Single‐Cell RNA Sequencing Reveals the Temporal Diversity and Dynamics of Cardiac Immunity after Myocardial Infarction

K Jin, S Gao, P Yang, R Guo, D Li, Y Zhang… - Small …, 2022 - Wiley Online Library
Myocardial infarction (MI) is strongly associated with the temporal regulation of cardiac
immunity. However, a variety of current clinical trials have failed because of the lack of post …

Tanshinone IIA ameliorates experimental diabetic cardiomyopathy by inhibiting endoplasmic reticulum stress in cardiomyocytes via SIRT1

S Wu, D Lu, B Gajendran, Q Hu, J Zhang… - Phytotherapy …, 2023 - Wiley Online Library
Diabetic cardiomyopathy (DCM) is a common complication in patients with diabetes, and
ultimately leads to heart failure. Endoplasmic reticulum stress (ERS) induced by abnormal …

Nanomedicine-based immunotherapy for Alzheimer's disease

M Hoque, A Samanta, SSM Alam, TA Zughaibi… - Neuroscience & …, 2023 - Elsevier
Alzheimer's disease (AD) is the most prevalent neurodegenerative disease caused by the
deposition of amyloid β (Aβ) fibrils forming extracellular plaques and the development of …

[HTML][HTML] Multifaceted pharmacological potentials of curcumin, genistein, and tanshinone IIA through proteomic approaches: an in-depth review

FB Khan, P Singh, YF Jamous, SA Ali, Abdullah… - Cancers, 2022 - mdpi.com
Simple Summary Over the years, alternative and complementary medicine have garnered
much attention all across the globe. To this end, phytochemicals have intriguing potential …

Biosynthesis and Regulatory Mechanisms of Bioactive Compounds in Salvia miltiorrhiza, a Model System for Medicinal Plant Biology

S Lu - Critical Reviews in Plant Sciences, 2021 - Taylor & Francis
Salvia miltiorrhiza is one of the most well known species in the genus Salvia of the
Lamiaceae with great economic, academic and medicinal value. It was recorded as a …

Tanshinone-IIA mediated neuroprotection by modulating neuronal pathways

K Sherawat, S Mehan - Naunyn-Schmiedeberg's Archives of …, 2023 - Springer
The progression of neurological diseases is mainly attributed to oxidative stress, apoptosis,
inflammation, and trauma, making them a primary public concern. Since no drugs can stop …

[HTML][HTML] Tanshinone-I for the treatment of uterine fibroids: Molecular docking, simulation, and density functional theory investigations

A Tiwari, V Tiwari, A Sharma, D Singh… - Saudi Pharmaceutical …, 2023 - Elsevier
Uterine fibroids (UF), most prevalent gynecological disorder, require surgery when
symptomatic. It is estimated that between 25 and 35 percent of women wait until the …