Triple negative breast cancer: Pitfalls and progress
P Zagami, LA Carey - NPJ Breast Cancer, 2022 - nature.com
Triple negative breast cancer (TNBC) is characterized by the lack of estrogen and
progesterone receptor expression and lacks HER2 overexpression or gene amplification. It …
progesterone receptor expression and lacks HER2 overexpression or gene amplification. It …
Going deep in medical image analysis: concepts, methods, challenges, and future directions
Medical image analysis is currently experiencing a paradigm shift due to deep learning. This
technology has recently attracted so much interest of the Medical Imaging Community that it …
technology has recently attracted so much interest of the Medical Imaging Community that it …
[PDF][PDF] Comprehensive analysis of genetic ancestry and its molecular correlates in cancer
We evaluated ancestry effects on mutation rates, DNA methylation, and mRNA and miRNA
expression among 10,678 patients across 33 cancer types from The Cancer Genome Atlas …
expression among 10,678 patients across 33 cancer types from The Cancer Genome Atlas …
Image analysis with deep learning to predict breast cancer grade, ER status, histologic subtype, and intrinsic subtype
HD Couture, LA Williams, J Geradts, SJ Nyante… - NPJ breast …, 2018 - nature.com
RNA-based, multi-gene molecular assays are available and widely used for patients with ER-
positive/HER2-negative breast cancers. However, RNA-based genomic tests can be costly …
positive/HER2-negative breast cancers. However, RNA-based genomic tests can be costly …
An approach for normalization and quality control for NanoString RNA expression data
A Bhattacharya, AM Hamilton, H Furberg… - Briefings in …, 2021 - academic.oup.com
The NanoString RNA counting assay for formalin-fixed paraffin embedded samples is
unique in its sensitivity, technical reproducibility and robustness for analysis of clinical and …
unique in its sensitivity, technical reproducibility and robustness for analysis of clinical and …
Spatial characterization of tumor-infiltrating lymphocytes and breast cancer progression
DJ Fassler, LA Torre-Healy, R Gupta, AM Hamilton… - Cancers, 2022 - mdpi.com
Simple Summary The assessment of tumor-infiltrating lymphocytes (TILs) is gaining
acceptance as a robust biomarker to help predict prognosis and treatment response. We …
acceptance as a robust biomarker to help predict prognosis and treatment response. We …
Association of race/ethnicity and the 21-gene recurrence score with breast cancer–specific mortality among US women
KF Hoskins, OC Danciu, NY Ko, GS Calip - JAMA oncology, 2021 - jamanetwork.com
Importance Given the widespread use of the 21-gene recurrence score for identifying
candidates for adjuvant chemotherapy, it is important to examine the performance of the …
candidates for adjuvant chemotherapy, it is important to examine the performance of the …
A framework for transcriptome-wide association studies in breast cancer in diverse study populations
A Bhattacharya, M García-Closas, AF Olshan… - Genome biology, 2020 - Springer
Background The relationship between germline genetic variation and breast cancer survival
is largely unknown, especially in understudied minority populations who often have poorer …
is largely unknown, especially in understudied minority populations who often have poorer …
Label-efficient deep learning in medical image analysis: Challenges and future directions
Deep learning has seen rapid growth in recent years and achieved state-of-the-art
performance in a wide range of applications. However, training models typically requires …
performance in a wide range of applications. However, training models typically requires …
Ten-year distant-recurrence risk prediction in breast cancer by CanAssist Breast (CAB) in Dutch sub-cohort of the randomized TEAM trial
Background Hormone receptor (HR)-positive, HER2/neu-negative breast cancers have a
sustained risk of recurrence up to 20 years from diagnosis. TEAM (Tamoxifen, Exemestane …
sustained risk of recurrence up to 20 years from diagnosis. TEAM (Tamoxifen, Exemestane …