Triple negative breast cancer: Pitfalls and progress

P Zagami, LA Carey - NPJ Breast Cancer, 2022 - nature.com
Triple negative breast cancer (TNBC) is characterized by the lack of estrogen and
progesterone receptor expression and lacks HER2 overexpression or gene amplification. It …

Going deep in medical image analysis: concepts, methods, challenges, and future directions

F Altaf, SMS Islam, N Akhtar, NK Janjua - IEEE Access, 2019 - ieeexplore.ieee.org
Medical image analysis is currently experiencing a paradigm shift due to deep learning. This
technology has recently attracted so much interest of the Medical Imaging Community that it …

[PDF][PDF] Comprehensive analysis of genetic ancestry and its molecular correlates in cancer

J Carrot-Zhang, N Chambwe, JS Damrauer… - Cancer Cell, 2020 - cell.com
We evaluated ancestry effects on mutation rates, DNA methylation, and mRNA and miRNA
expression among 10,678 patients across 33 cancer types from The Cancer Genome Atlas …

Image analysis with deep learning to predict breast cancer grade, ER status, histologic subtype, and intrinsic subtype

HD Couture, LA Williams, J Geradts, SJ Nyante… - NPJ breast …, 2018 - nature.com
RNA-based, multi-gene molecular assays are available and widely used for patients with ER-
positive/HER2-negative breast cancers. However, RNA-based genomic tests can be costly …

An approach for normalization and quality control for NanoString RNA expression data

A Bhattacharya, AM Hamilton, H Furberg… - Briefings in …, 2021 - academic.oup.com
The NanoString RNA counting assay for formalin-fixed paraffin embedded samples is
unique in its sensitivity, technical reproducibility and robustness for analysis of clinical and …

Spatial characterization of tumor-infiltrating lymphocytes and breast cancer progression

DJ Fassler, LA Torre-Healy, R Gupta, AM Hamilton… - Cancers, 2022 - mdpi.com
Simple Summary The assessment of tumor-infiltrating lymphocytes (TILs) is gaining
acceptance as a robust biomarker to help predict prognosis and treatment response. We …

Association of race/ethnicity and the 21-gene recurrence score with breast cancer–specific mortality among US women

KF Hoskins, OC Danciu, NY Ko, GS Calip - JAMA oncology, 2021 - jamanetwork.com
Importance Given the widespread use of the 21-gene recurrence score for identifying
candidates for adjuvant chemotherapy, it is important to examine the performance of the …

A framework for transcriptome-wide association studies in breast cancer in diverse study populations

A Bhattacharya, M García-Closas, AF Olshan… - Genome biology, 2020 - Springer
Background The relationship between germline genetic variation and breast cancer survival
is largely unknown, especially in understudied minority populations who often have poorer …

Label-efficient deep learning in medical image analysis: Challenges and future directions

C Jin, Z Guo, Y Lin, L Luo, H Chen - arXiv preprint arXiv:2303.12484, 2023 - arxiv.org
Deep learning has seen rapid growth in recent years and achieved state-of-the-art
performance in a wide range of applications. However, training models typically requires …

Ten-year distant-recurrence risk prediction in breast cancer by CanAssist Breast (CAB) in Dutch sub-cohort of the randomized TEAM trial

X Zhang, A Gunda, EMK Kranenbarg, GJ Liefers… - Breast Cancer …, 2023 - Springer
Background Hormone receptor (HR)-positive, HER2/neu-negative breast cancers have a
sustained risk of recurrence up to 20 years from diagnosis. TEAM (Tamoxifen, Exemestane …