The development of essential hypertension involves several factors. Vascular dysfunction,
characterized by endothelial dysfunction, low-grade inflammation and structural remodeling …

The blood–brain barrier (BBB) is an interface primarily comprised of brain endothelial cells
(BECs), separating the central nervous system (CNS) from the systemic circulation while …

The metabolic syndrome is a condition characterized by the co-existence of several major
risk factors for cardiovascular disease (CVD)–high blood pressure, hyperglycaemia, and …

Aging of the vasculature is characterized by endothelial dysfunction and arterial stiffening,
two key events in the pathogenesis of cardiovascular disease (CVD). Treatment with sodium …

Several clinical and large population studies indicate that women are more salt-sensitive
than men, yet the precise mechanisms by which the sexually dimorphic onset manifests …

Evidence links osteoporosis and cardiovascular disease but the cellular and molecular
mechanisms are unclear. Here we identify skeleton-secreted platelet-derived growth factor …

This review discusses sexual dimorphism in arterial stiffening, disease pathology
interactions, and the influence of sex on mechanisms and pathways. Arterial stiffness …

Activation of the mineralocorticoid receptor (MR) in the distal nephron by its ligand,
aldosterone, plays an important role in sodium reabsorption and blood pressure regulation …

Abstract Purpose of Review To update and review novel insights into the mechanisms,
measurements, and therapeutic approaches to arterial stiffness. Recent Findings Arterial …

Nearly all cardiovascular diseases show sexual dimorphisms in prevalence, presentation,
and outcomes. Until recently, most clinical trials were carried out in males, and many animal …