Objective Elevated aldosterone is associated with increased risk of atherosclerosis
complications, whereas treatment with mineralocorticoid receptor (MR) antagonists …

The mineralocorticoid receptor (MR) was originally identified as a regulator of blood
pressure, able to modulate renal sodium handling in response to its principal ligand …

Originally described as the renal aldosterone receptor that regulates sodium homeostasis, it
is now clear that mineralocorticoid receptors (MRs) are widely expressed, including in …

Epithelial Na+ channels (ENaCs) are members of the ENaC/degenerin family of ion
channels that evolved to respond to extracellular factors. In addition to being expressed in …

Background: The remarkable success of clinical trials in mineralocorticoid receptor (MR)
inhibition in heart failure has driven research on the physiological and pathological role (s) …

Over the past decade, several studies have shown that activity of extra-renal
mineralocorticoid receptors (MR) regulates vascular tone, adipogenesis, adipose tissue …

Aging is associated with heart and vascular dysfunction that contributes to cardiovascular
disease (CVD) risk. Clinical data support a sexual dimorphism in the time course of aging …

Since the mineralocorticoid receptor (MR) was cloned 30 years ago, it has become clear that
MR is expressed in extra-renal tissues, including the cardiovascular system, where it is …

Perivascular adipose tissue (PVAT) is a special type of ectopic fat depot that adheres to most
vasculatures. PVAT has been shown to exert anticontractile effects on the blood vessels and …

Background The incidence of obesity is rising, particularly among women. Microvascular
dysfunction is more common with female sex, obesity, and hyperlipidemia and predicts …