Obesity impairs endothelial-mediated vasodilation, the earliest step in vascular disease and
a contributor to hypertension. We previously demonstrated that endothelial cell MR …

Abstract Purpose of Review To review the latest reports of the contributions of the
endothelial mineralocorticoid receptor to endothelial dysfunction and hypertension to begin …

Purpose Accumulating evidence has demonstrated the existence of extra-adrenal
aldosterone in various tissues, including the brain, heart, vascular, adipocyte, and kidney …

Aldosterone is a key factor in adverse cardiovascular remodeling by acting on the
mineralocorticoid receptor (MR) in different cell types. Endothelial MR activation mediates …

Introduction High salt intake and aldosterone are both associated with vascular stiffening in
humans. However, our preliminary work showed that high dietary salt alone did not increase …

Objective Aortic vascular stiffness has been implicated in the development of cardiovascular
disease (CVD) and chronic kidney disease (CKD) in obese individuals. However, the …

We recently showed that Western diet–induced obesity and insulin resistance promotes
endothelial cortical stiffness in young female mice. Herein, we tested the hypothesis that …

Neuraminidases cleave sialic acids from glycocalyx structures and plasma neuraminidase
activity is elevated in type 2 diabetes (T2D). Therefore, we hypothesize circulating …

Insulin resistance in the vasculature is a characteristic feature of obesity and contributes to
the pathogenesis of vascular dysfunction and disease. However, the molecular mechanisms …

The mineralocorticoid receptor (MR) is indispensable for survival through its critical role in
maintaining blood pressure in response to sodium scarcity or bleeding. Activation of MR by …