Mineralocorticoid receptor (MR) activation plays an important role in hepatic insulin
resistance. However, the precise mechanisms by which MR activation promotes hepatic …

In the past, it was believed that the expression of the epithelial sodium channel (ENaC) was
restricted to epithelial tissues, such as the distal nephron, airway, sweat glands, and colon …

Sustained stimulation of β-adrenoceptors (β-ARs) and activation of renin–angiotensin–
aldosterone system are common features of cardiovascular diseases with rising sympathetic …

Sphingomyelinases ensure ceramide production and play an integral role in cell turnover,
inward budding of vesicles and outward release of exosomes. Recent data indicate a …

Recent advances in the field of mineralocorticoid receptor (MR) and its ligand aldosterone
expanded the role of this hormone and its receptor far beyond their initial function as a …

Consumption of diets high in fat, sugar, and salt (Western diet, WD) is associated with
accelerated arterial stiffening, a major independent risk factor for cardiovascular disease …

Encouraging changes in the steroid hormone receptor field from initially questioning the role
of non-genomic actions of steroid hormones to acceptance of the concept that the acute …

Mineralocorticoid receptor activation in endothelial and smooth muscle cells can promote
vascular disease by increasing oxidative stress, promoting inflammation, accelerating …

Obstructive sleep apnea (OSA) is a chronic and highly prevalent condition that is associated
with oxidative stress, inflammation, and fibrosis, leading to endothelial dysfunction, arterial …

Background Recent evidence by our laboratory demonstrates that women and female mice
endogenously express higher endothelial mineralocorticoid receptor (ECMR) than males …