The contribution of genetic inheritance in multiple sclerosis was established early on.
Although multiple sclerosis is not a Mendelian disease, its incidence and prevalence is …

Local synthesis of antibodies and presence of oligoclonal bands in the cerebrospinal fluid
(CSF) are hallmarks of multiple sclerosis (MS). We investigated the frequency of antibodies …

Abstract Background Oligoclonal IgM (OCMB) and IgG (OCGB) bands were found to be
associated with poor multiple sclerosis (MS) prognosis. Objective We aimed to evaluate the …

Clonally related B cells infiltrate the brain, meninges, and cerebrospinal fluid of MS patients,
but the mechanisms driving the B‐cell response and shaping the immunoglobulin …

Background: Vitamin D deficit is considered an important risk factor for many inflammatory
and autoimmune diseases. Objective: To investigate the influence of the multiple sclerosis …

Immunoglobulin gamma (IgG) heavy chain genes are associated with susceptibility to
multiple sclerosis (MS) and IgG levels in the cerebrospinal fluid (CSF). However, how these …

Introduction Natalizumab (NTZ) can be associated with an opportunistic infection,
progressive multifocal leukoencephalopathy (PML), caused by John Cunningham virus …

We have previously shown that plasmablasts of the G1m1 allotype of IgG1 are selectively
enriched in the cerebrospinal fluid of G1m1/G1m3 heterozygous patients with multiple …

Abstract Guillain-Barré Syndrome (GBS) is an acute, immune-mediated
polyradiculoneuropathy with high burden of disability and unpredictable course. Biomarkers …

Local synthesis of IgG in the CNS is present in> 90% of patients with multiple sclerosis (MS),
and is considered a hallmark of the disease. A recent study has discovered genetic factors …