Dendritic cell subsets in cancer immunity and tumor antigen sensing
Dendritic cells (DCs) exhibit a specialized antigen-presenting function and play crucial roles
in both innate and adaptive immune responses. Due to their ability to cross-present tumor …
in both innate and adaptive immune responses. Due to their ability to cross-present tumor …
Radiotherapy combined with immunotherapy: the dawn of cancer treatment
Z Zhang, X Liu, D Chen, J Yu - Signal Transduction and Targeted …, 2022 - nature.com
Radiotherapy (RT) is delivered for purposes of local control, but can also exert systemic
effect on remote and non-irradiated tumor deposits, which is called abscopal effect. The view …
effect on remote and non-irradiated tumor deposits, which is called abscopal effect. The view …
SLC38A2 and glutamine signalling in cDC1s dictate anti-tumour immunity
C Guo, Z You, H Shi, Y Sun, X Du, G Palacios, C Guy… - Nature, 2023 - nature.com
Cancer cells evade T cell-mediated killing through tumour–immune interactions whose
mechanisms are not well understood,. Dendritic cells (DCs), especially type-1 conventional …
mechanisms are not well understood,. Dendritic cells (DCs), especially type-1 conventional …
A RORγt+ cell instructs gut microbiota-specific Treg cell differentiation
The mutualistic relationship of gut-resident microbiota and the host immune system
promotes homeostasis that ensures maintenance of the microbial community and of a …
promotes homeostasis that ensures maintenance of the microbial community and of a …
[HTML][HTML] Dendritic cell type 3 arises from Ly6C+ monocyte-dendritic cell progenitors
Conventional dendritic cells (cDCs) are professional antigen-presenting cells that control the
adaptive immune response. Their subsets and developmental origins have been intensively …
adaptive immune response. Their subsets and developmental origins have been intensively …
Lactate limits CNS autoimmunity by stabilizing HIF-1α in dendritic cells
Dendritic cells (DCs) have a role in the development and activation of self-reactive
pathogenic T cells,. Genetic variants that are associated with the function of DCs have been …
pathogenic T cells,. Genetic variants that are associated with the function of DCs have been …
Dendritic cells can prime anti-tumor CD8+ T cell responses through major histocompatibility complex cross-dressing
BW MacNabb, X Chen, S Tumuluru, J Godfrey… - Immunity, 2022 - cell.com
Antigen cross-presentation, wherein dendritic cells (DCs) present exogenous antigen on
major histocompatibility class I (MHC-I) molecules, is considered the primary mechanism by …
major histocompatibility class I (MHC-I) molecules, is considered the primary mechanism by …
Trial watch: Dendritic cell (DC)-based immunotherapy for cancer
Dendritic cell (DC)-based vaccination for cancer treatment has seen considerable
development over recent decades. However, this field is currently in a state of flux toward …
development over recent decades. However, this field is currently in a state of flux toward …
Transitional dendritic cells are distinct from conventional DC2 precursors and mediate proinflammatory antiviral responses
FB Sulczewski, RA Maqueda-Alfaro… - Nature …, 2023 - nature.com
High-dimensional approaches have revealed heterogeneity amongst dendritic cells (DCs),
including a population of transitional DCs (tDCs) in mice and humans. However, the origin …
including a population of transitional DCs (tDCs) in mice and humans. However, the origin …
The role of dendritic cells in cancer and anti-tumor immunity
AE Marciscano, N Anandasabapathy - Seminars in immunology, 2021 - Elsevier
Dendritic cells (DC) are key sentinels of the host immune response with an important role in
linking innate and adaptive immunity and maintaining tolerance. There is increasing …
linking innate and adaptive immunity and maintaining tolerance. There is increasing …