Co‐based Nanozymatic Profiling: Advances Spanning Chemistry, Biomedical, and Environmental Sciences

J Li, X Cai, P Jiang, H Wang, S Zhang, T Sun… - Advanced …, 2024 - Wiley Online Library
Nanozymes, next‐generation enzyme‐mimicking nanomaterials, have entered an era of
rational design; among them, Co‐based nanozymes have emerged as captivating players …

[HTML][HTML] Systemic review of biodegradable nanomaterials in nanomedicine

S Su, PM Kang - Nanomaterials, 2020 - mdpi.com
Background: Nanomedicine is a field of science that uses nanoscale materials for the
diagnosis and treatment of human disease. It has emerged as an important aspect of the …

A thrombin‐activated peptide‐templated nanozyme for remedying ischemic stroke via thrombolytic and neuroprotective actions

Z Wang, Y Zhao, Y Hou, G Tang, R Zhang… - Advanced …, 2024 - Wiley Online Library
Ischemic stroke (IS) is one of the most common causes of disability and death. Thrombolysis
and neuroprotection are two current major therapeutic strategies to overcome ischemic and …

[HTML][HTML] Exosomal miR-155 from M1-polarized macrophages promotes EndoMT and impairs mitochondrial function via activating NF-κB signaling pathway in vascular …

X Ge, P Tang, Y Rong, D Jiang, X Lu, C Ji, J Wang… - Redox biology, 2021 - Elsevier
Abstract Pathologically, blood-spinal-cord-barrier (BSCB) disruption after spinal cord injury
(SCI) leads to infiltration of numerous peripheral macrophages into injured areas and …

Advances in biomaterial‐based spinal cord injury repair

H Shen, C Fan, Z You, Z Xiao… - Advanced Functional …, 2022 - Wiley Online Library
Spinal cord injury (SCI) often leads to the loss of motor and sensory functions and is a major
challenge in neurological clinical practice. Understanding the pathophysiological changes …

[HTML][HTML] Antioxidant therapy in oxidative stress-induced neurodegenerative diseases: Role of nanoparticle-based drug delivery systems in clinical translation

A Ashok, SS Andrabi, S Mansoor, Y Kuang, BK Kwon… - Antioxidants, 2022 - mdpi.com
Free radicals are formed as a part of normal metabolic activities but are neutralized by the
endogenous antioxidants present in cells/tissue, thus maintaining the redox balance. This …

Oxidative stress following spinal cord injury: From molecular mechanisms to therapeutic targets

M Yu, Z Wang, D Wang, M Aierxi, Z Ma… - Journal of …, 2023 - Wiley Online Library
Spinal cord injury (SCI) is a medical condition that results from severe trauma to the central
nervous system; it imposes great psychological and economic burdens on affected patients …

Engineering CXCL12 biomimetic decoy‐integrated versatile immunosuppressive nanoparticle for ischemic stroke therapy with Management of Overactivated Brain …

J Shi, Y Yang, N Yin, C Liu, Y Zhao, H Cheng… - Small …, 2022 - Wiley Online Library
Following ischemic stroke, brain‐resident activated microglia and peripherally infiltrated
inflammatory cells create a complicated and overactivated brain immune microenvironment …

Nanoscale drug delivery systems for controllable drug behaviors by multi-stage barrier penetration

J Wang, Q Ni, Y Wang, Y Zhang, H He, D Gao… - Journal of Controlled …, 2021 - Elsevier
Due to the poor physicochemical properties of drugs and multi-stage biological barriers in
vivo, drugs at action site cannot reach up to sufficient concentration to acquire expected …

[HTML][HTML] Trehalose inhibits ferroptosis via NRF2/HO-1 pathway and promotes functional recovery in mice with spinal cord injury

F Gong, T Ge, J Liu, J Xiao, X Wu, H Wang… - Aging (Albany …, 2022 - ncbi.nlm.nih.gov
Spinal cord injury (SCI) is the main cause of severe damage to the central nervous system
and leads to irreversible tissue loss and neurological dysfunction. Ferroptosis is a cell death …