TCM network pharmacology: a new trend towards combining computational, experimental and clinical approaches

W Xin, W Zi-Yi, JH Zheng, LI Shao - Chinese journal of natural medicines, 2021 - Elsevier
Traditional Chinese medicine (TCM) is a precious treasure of the Chinese nation and has
unique advantages in the prevention and treatment of diseases. The holistic view of TCM …

[PDF][PDF] 网络药理学与中医药现代研究的若干进展

张彦琼, 李梢 - 中国药理学与毒理学杂志, 2015 - cjpt.magtechjournal.com
中医药具有以整体观和辨证论治为特色的理论体系和几千年的临床实践经验,
中医药现代化亟需建立符合其整体特点的科学研究方法. 随着医学与生命科学研究步入大数据 …

Multi-target therapeutics for neuropsychiatric and neurodegenerative disorders

P Bawa, P Pradeep, P Kumar, YE Choonara, G Modi… - Drug discovery today, 2016 - Elsevier
Highlights•The polygenic nature of neuro-affected disorders favors multi-targeted drug
design.•Revisions of major diagnostic systems support DMLs for neuropsychiatric …

[HTML][HTML] Modular screening reveals driver induced additive mechanisms of baicalin and jasminoidin on cerebral ischemia therapy

B Li, Y Wang, H Gu, Y Yu, P Wang, J Liu… - Frontiers in …, 2022 - frontiersin.org
Combination therapy with increased efficacy and reduced toxicity plays a crucial role in
treating complex diseases, such as stroke, but it remains an insurmountable barrier to …

[HTML][HTML] Application of network composite module analysis and verification to explore the bidirectional immunomodulatory effect of Zukamu granules on Th1/Th2 …

Y Li, S Li, M Gu, G Liu, Y Li, Z Ji, K Li, Y Wang… - Journal of …, 2022 - Elsevier
Ethnopharmacological relevance Zukamu granules (ZKMG), as the preferred drug for the
treatment of colds in Uygur medical theory, has been used for 1500 years. It is also widely …

Dose-dependent target diversion of Danhong injection on the Glu-GLT-1/Gly-GlyRα dynamic balance module of cerebral ischemia

W Xu, Y Zhang, Y Yu, B Li, J Liu, P Wang, H Wu… - Pharmacological …, 2018 - Elsevier
Function-oriented modular structure analysis is a great challenge in module-based
pharmacological studies. A strategy to uncover target-target interaction (TTI) and dynamic …

[HTML][HTML] Intermodule coupling analysis of huang-lian-jie-du decoction on stroke

P Wang, L Dai, W Zhou, J Meng, M Zhang… - Frontiers in …, 2019 - frontiersin.org
Huang-Lian-Jie-Du Decoction (HLJDD) is a" Fangji" made up of well-designed Chinese
herb array and widely used to treat ischemic stroke. Here we aimed to investigate …

[HTML][HTML] Identifying Qingkailing (清开灵) ingredients-dependent mesenchymal-epithelial transition factor-axiation “π” structuring module with angiogenesis and …

K Cheng, Y Jianan, LIU Jun, S Zhang… - Journal of Traditional …, 2024 - ncbi.nlm.nih.gov
OBJECTIVE: To explore the functional role of the drug-dependent mesenchymal-epithelial
transition (Met)-axiation" π" structural module of neurogenesis after processing by three …

Endotype-driven Co-module Mechanisms of Danhong Injection in the Co-treatment of Cardiovascular and Cerebrovascular Diseases: A Modular-based Drug and …

S Zhang, Q Niu, W Zong, Q Song, S Tian… - Journal of …, 2024 - Elsevier
Ethnopharmacological relevance Cardiovascular and cerebrovascular diseases are the
leading causes of death worldwide and interact closely with each other. Danhong Injection …

[HTML][HTML] The material basis and mechanism of Xuefu Zhuyu decoction in treating stable Angina Pectoris and unstable angina pectoris

G Qi, K Jiang, J Qu, A Zhang, Z Xu, Z Li… - Evidence-based …, 2022 - hindawi.com
Background and Objective. Xuefu Zhuyu decoction has good efficacy in both stable and
unstable angina pectoris; however, the reasons for this remain elusive. We propose a …