Opposing, spatially-determined epigenetic forces impose restrictions on stochastic olfactory receptor choice
EV Bashkirova, N Klimpert, K Monahan, CE Campbell… - Elife, 2023 - elifesciences.org
Olfactory receptor (OR) choice represents an example of genetically hardwired stochasticity,
where every olfactory neuron expresses one out of~ 2000 OR alleles in the mouse genome …
where every olfactory neuron expresses one out of~ 2000 OR alleles in the mouse genome …
Human organoids for the study of retinal development and disease
CM Bell, DJ Zack, CA Berlinicke - Annual review of vision …, 2020 - annualreviews.org
Recent advances in stem cell engineering have led to an explosion in the use of organoids
as model systems for studies in multiple biological disciplines. Together with breakthroughs …
as model systems for studies in multiple biological disciplines. Together with breakthroughs …
Deep transfer learning for clinical decision-making based on high-throughput data: comprehensive survey with benchmark results
The rapid growth of omics-based data has revolutionized biomedical research and precision
medicine, allowing machine learning models to be developed for cutting-edge performance …
medicine, allowing machine learning models to be developed for cutting-edge performance …
Transplantation of miPSC/mESC-derived retinal ganglion cells into healthy and glaucomatous retinas
Optic neuropathies, including glaucoma, are a group of neurodegenerative diseases,
characterized by the progressive loss of retinal ganglion cells (RGCs), leading to irreversible …
characterized by the progressive loss of retinal ganglion cells (RGCs), leading to irreversible …
Single-cell RNA sequencing in vision research: Insights into human retinal health and disease
Gene expression provides valuable insight into cell function. As such, vision researchers
have frequently employed gene expression studies to better understand retinal physiology …
have frequently employed gene expression studies to better understand retinal physiology …
Impairing Gasdermin D-mediated pyroptosis is protective against retinal degeneration
Background Inflammasome activation and the subsequent release of pro-inflammatory
cytokines including Interleukin 1β (IL-1β) have been widely reported to contribute to the …
cytokines including Interleukin 1β (IL-1β) have been widely reported to contribute to the …
Single-cell RNA-sequencing of mammalian brain development: insights and future directions
E Vinsland, S Linnarsson - Development, 2022 - journals.biologists.com
Understanding human brain development is of fundamental interest but is also very
challenging. Single-cell RNA-sequencing studies in mammals have revealed that brain …
challenging. Single-cell RNA-sequencing studies in mammals have revealed that brain …
ASCOT identifies key regulators of neuronal subtype-specific splicing
Public archives of next-generation sequencing data are growing exponentially, but the
difficulty of marshaling this data has led to its underutilization by scientists. Here, we present …
difficulty of marshaling this data has led to its underutilization by scientists. Here, we present …
Single cell transcriptomics reveals lineage trajectory of retinal ganglion cells in wild-type and Atoh7-null retinas
Atoh7 has been believed to be essential for establishing the retinal ganglion cell (RGC)
lineage, and Pou4f2 and Isl1 are known to regulate RGC specification and differentiation …
lineage, and Pou4f2 and Isl1 are known to regulate RGC specification and differentiation …
Single-cell RNA sequencing of the retina in a model of retinitis pigmentosa reveals early responses to degeneration in rods and cones
D Karademir, V Todorova, LJA Ebner, M Samardzija… - BMC biology, 2022 - Springer
Background In inherited retinal disorders such as retinitis pigmentosa (RP), rod
photoreceptor-specific mutations cause primary rod degeneration that is followed by …
photoreceptor-specific mutations cause primary rod degeneration that is followed by …