Virus-specific CD8+ T cells that differentiate in the context of resolved versus persisting
infections exhibit divergent phenotypic and functional characteristics, which suggests that …

Tissue-resident-memory CD8+ T cells (T RM) have been described as a non-circulating
memory T cell subset that persists at sites of previous infection. While T RM in all non …

The central nervous system (CNS) is classically viewed as immune-privileged; however,
recent advances highlight interactions between the peripheral immune system and CNS in …

Some breast tumors metastasize aggressively whereas others remain dormant for years.
The mechanism governing metastatic dormancy remains largely unknown. Through high …

Autoimmune diseases can afflict every organ system, including blood vessels that are
critically important for host survival. The most frequent autoimmune vasculitis is giant cell …

Increasing global concerns of pandemic respiratory viruses highlight the importance of
developing optimal vaccination strategies that encompass vaccine platform, delivery route …

Aging is generally characterized as a gradual increase in tissue damage, which is
associated with senescence and chronic systemic inflammation and is evident in a variety of …

Metastasis is an intricate process whereby tumor cells migrate from the primary tumor,
survive in the circulation, seed distal organs, and proliferate to create metastatic foci. CD8+ T …

Tissue-resident memory CD8 T cells are responsible for local immune surveillance in
different tissues, including the brain. They constitute the first line of defense against …

Effective adaptive immune responses are characterized by stages of development and
maturation of T and B cell populations that respond to disturbances in the host homeostasis …