Recent advances in the development of nitrogen-containing heterocyclic anti-Alzheimer's agents

A Kumar, B Nehra, D Singh, D Kumar… - Current Topics in …, 2023 - ingentaconnect.com
Alzheimer's disease (AD) remains one of the major neurodegenerative diseases
overwhelming the world today. Alzheimer's is the most complicated as well as perplexing …

Synthesis and biological activity of pyrrolidine/piperidine substituted 3-amido-9-ethylcarbazole derivatives

S Sirin, H Duyar, B Aslım, Z Seferoğlu - Journal of Molecular Structure, 2021 - Elsevier
In this study, pyrrolidine/piperidine substituted 3-amido-9-ethylcarbazole derivatives were
synthesized and characterized by FT-IR, 1 H NMR, 13 C NMR spectroscopic and HRMS …

Design, Synthesis, and Cytotoxic Activities of Indole and Indazole‐Based Stilbenes

Z Ma, W Zhang, X Han, Y Chen, G Li - Chemistry & Biodiversity, 2023 - Wiley Online Library
To develop new highly effective anticancer agents derived from naturally occurring stilbene
scaffold, in total of 24 indole and indazole‐based stilbenes including 17 new compounds …

[HTML][HTML] In vitro enzymatic and kinetic studies, and in silico drug-receptor interactions, and drug-like profiling of the 5-styrylbenzamide derivatives as potential …

MJ Mphahlele, EN Agbo, GK More, S Gildenhuys - Antioxidants, 2021 - mdpi.com
The 5-(styryl) anthranilamides were transformed into the corresponding 5-styryl-2-(p-
tolylsulfonamido) benzamide derivatives. These 5-styrylbenzamide derivatives were …

1, 3-Bis (((E)-(9-ethyl-9H-carbazol-3-yl) methylene) amino) propan-2-ol: Synthesis, Characterization DFT Study, and Acetylcholinesterase Inhibitory Activity

F Çelik, N Süleymanoğlu, R Ustabaş, E Bektaş… - Russian Journal of …, 2023 - Springer
Abstract The carbazole derivative, 1, 3-bis (((E)-(9-ethyl-9H-carbazol-3-yl) methylene)
amino) propan-2-ol (compound I), was synthesized and its molecular structure was verified …

[PDF][PDF] A comprehensive review of cholinesterase modeling and simulation. Biomolecules. 2021; 11: 580

D De Boer, N Nguyen, J Mao, J Moore… - Cholinesterase Research, 2021 - mdpi.com
The present article reviews published efforts to study acetylcholinesterase and
butyrylcholinesterase structure and function using computer-based modeling and simulation …

[HTML][HTML] Atividade anti-Alzheimer de substâncias oriundas de produtos naturais e de origem sintética: alguns exemplos importantes dos últimos 20 anos

ABS Vellosa, VB Lima Filho, BA Soares… - Química …, 2022 - SciELO Brasil
Alzheimer's disease has about 9.9 million new cases annually, according to World Health
Organization. Due to the increasing incidence of people affected by AD and the absence of …

[HTML][HTML] Alzheimer hastalığı ve anti-Alzheimer etkili bileşiklerin yapılarının araştırılması

Ö Tarı, R Yağmurtaşan - Hacettepe University Journal of the Faculty …, 2023 - dergipark.org.tr
Demansın en yaygın şekli olan Alzheimer hastalığı, hafıza kaybı ve diğer bilişsel problemler
ile karakterize karmaşık bir hastalıktır. Artan prevalansa sahip olan Alzheimer hastalığının …

Exploration of potent multi-target-directed-ligands as anti-alzheimer's disease agents: A moiety based review

P Teli, N Sahiba, J Soni, A Sethiya… - Mini Reviews in …, 2021 - ingentaconnect.com
Dementia is a chronic neurodegenerative disease, and a maximum number of the cases are
directly related to Alzheimer's disease. More than 4 million people are living with Alzheimer's …

Recent Development of Hybrids and Derivatives of Resveratrol in Neurodegenerative Diseases

B De Filippis, M Fantacuzzi - Flavonoids and Phenolics, 2022 - books.google.com
Neurodegenerative diseases (NDs) are characterized by the progressive loss of neurons in
different regions of the nervous system, being Alzheimer's disease (AD) and Parkinson's …