Engineered exosomes from different sources for cancer-targeted therapy

M Zhang, S Hu, L Liu, P Dang, Y Liu, Z Sun… - Signal transduction and …, 2023 - nature.com
Exosome is a subgroup of extracellular vesicles, which has been serving as an efficient
therapeutic tool for various diseases. Engineered exosomes are the sort of exosomes …

Advances in drug delivery systems based on red blood cells and their membrane-derived nanoparticles

PHD Nguyen, MK Jayasinghe, AH Le, B Peng… - ACS nano, 2023 - ACS Publications
Red blood cells (RBCs) and RBC membrane-derived nanoparticles have been historically
developed as bioinspired drug delivery systems to combat the issues of premature …

Homologous cancer cell membrane-camouflaged nanoparticles target drug delivery and enhance the chemotherapy efficacy of hepatocellular carcinoma

Y Wu, R Zhu, M Zhou, J Liu, K Dong, S Zhao, J Cao… - Cancer letters, 2023 - Elsevier
Hepatocellular carcinoma (HCC) is a common digestive tract malignancy that seriously
threatens human life and health. Early HCC may be treated by intervention, surgery, and …

Red blood cell-derived extracellular vesicles display endogenous antiviral effects and enhance the efficacy of antiviral oligonucleotide therapy

MK Jayasinghe, C Gao, G Yap, BZJ Yeo, LT Vu… - ACS …, 2023 - ACS Publications
The COVID-19 pandemic has resulted in a large number of fatalities and, at present, lacks a
readily available curative treatment for patients. Here, we demonstrate that unmodified red …

Endocytosis of red blood cell extracellular vesicles by macrophages leads to cytoplasmic heme release and prevents foam cell formation in atherosclerosis

TT Pham, AH Le, CP Dang, SY Chong… - Journal of …, 2023 - Wiley Online Library
Extracellular vesicles (EVs) can be produced from red blood cells (RBCs) on a large scale
and used to deliver therapeutic payloads efficiently. However, not much is known about the …

Extracellular vesicles as new players in drug delivery: a focus on red blood cells-derived EVs

S Biagiotti, F Abbas, M Montanari, C Barattini, L Rossi… - Pharmaceutics, 2023 - mdpi.com
The article is divided into several sections, focusing on extracellular vesicles'(EVs) nature,
features, commonly employed methodologies and strategies for their isolation/preparation …

Recent advances in bacteria-based cancer treatment

X Wei, M Du, Z Chen, Z Yuan - Cancers, 2022 - mdpi.com
Simple Summary Cancer refers to a disease involving abnormal cells that proliferate
uncontrollably and can invade normal body tissue. It was estimated that at least 9 million …

[HTML][HTML] Endosomal escape of nucleic acids from extracellular vesicles mediates functional therapeutic delivery

TT Pham, H Chen, PHD Nguyen, MK Jayasinghe… - Pharmacological …, 2023 - Elsevier
Extracellular vesicles hold great promise as a drug delivery platform for RNA-based
therapeutics. However, there is a lack of experimental evidence for the intracellular …

Targeting Senescent Alveolar Epithelial Cells Using Engineered Mesenchymal Stem Cell-Derived Extracellular Vesicles To Treat Pulmonary Fibrosis

Y Long, B Yang, Q Lei, F Gao, L Chen, W Chen… - ACS …, 2024 - ACS Publications
Type 2 alveolar epithelial cell (AEC2) senescence is crucial to the pathogenesis of
pulmonary fibrosis (PF). The nicotinamide adenine dinucleotide (NAD+)-consuming enzyme …

Extracellular vesicles and lipoproteins–Smart messengers of blood cells in the circulation

PHD Nguyen, AH Le, JSQ Pek, TT Pham… - Journal of …, 2022 - Wiley Online Library
Blood cell‐derived extracellular vesicles (BCEVs) and lipoproteins are the major circulating
nanoparticles in blood that play an important role in intercellular communication. They have …