There have been many advances in our knowledge about different aspects of P2Y receptor
signaling since the last review published by our International Union of Pharmacology …

In 1929 Drury and Szent-Györgyi published a seminal paper describing the potent actions of
adenine compounds. Some decades later, adenosine 5'-triphosphate (ATP) was proposed …

Cells must amplify external signals to orient and migrate in chemotactic gradient fields. We
find that human neutrophils release adenosine triphosphate (ATP) from the leading edge of …

Purinergic signaling plays important roles in control of vascular tone and remodeling. There
is dual control of vascular tone by ATP released as a cotransmitter with noradrenaline from …

Abstract Pannexin-1 (Panx1) channels have been shown to regulate leukocyte trafficking
and tissue inflammation but the mechanism of Panx1 in chronic vascular diseases like …

The role of ATP as an extracellular signalling molecule is now well established and
evidence is accumulating that ATP and other nucleotides (ADP, UTP and UDP) play …

Permeability edema is a life-threatening complication accompanying acute lung injury (ALI),
severe pneumonia and the acute respiratory distress syndrome (ARDS), which can be …

The P2X4 receptor has a widespread distribution in the central nervous system and the
periphery, and plays an important role in the function of immune cells and the vascular …

Objective—ADP plays an important role in platelet aggregation by activating P2Y12
receptors. We assessed the hypothesis that P2Y12 receptors are expressed in vascular …

Abstract Background Extracellular nucleotides (ATP, ADP, UTP and UDP) exert a wide
range of biological effects in blood cells mediated by multiple ionotropic P2X receptors and …