Fifteen years after the first demonstration of epigenetic tumor-suppressor gene inactivation
associated with promoter methylation, the field has reached a level of understanding that …

Multidrug resistance (MDR) of cancer cells to cytostatic agents is the major obstacle for the
succesfull chemotherapy. One of the causes of the development of cellular resistance to a …

Overexposure of the human skin to solar ultraviolet (UV) radiation is the major etiologic
factor for development of skin cancers. Here, we report the results of epigenetic …

Background The purpose of this study was to investigate the potential role of variable
microRNA (miRNA) expression in the development of multidrug resistance (MDR) in head …

Nuclear transfer experiments have demonstrated that epigenetic mechanisms operate to
limit gene expression during animal development. In somatic cells, silenced genes are …

It has become apparent that epigenetically mediated alterations, which establish heritable
abnormalities in gene expression, are a fundamental feature of human cancer. The best …

ATP-binding cassette (ABC) transporters play a crucial role in multidrug resistance (MDR) of
cancers. They function as efflux pumps, resulting in limited effectiveness or even failure of …

Seizures cannot be medically controlled in approximately 40% of people with epilepsy.
Although we are beginning to understand how to better treat certain seizure types, we still do …

To elucidate the role of epigenetic reprogramming in cell-or tissue-specific differentiation, we
explored the role of DNA methyltransferases (Dnmts) in the nerve growth factor (NGF) …

In recent years, the different classes of drugs and regimens used clinically have provided an
improvement in tumour management. However, treatment is often palliative for the majority …