Acquired drug resistance is a primary obstacle for effective cancer therapy. The correlation
of point mutations in class III β-tubulin (TUBB3) and the prominent overexpression of ATP …

Colorectal carcinoma (CRC) is a complicated and often fatal genetic disease. Fortunately,
owing to rapid expansion of knowledge and technology development in oncology, much …

DNA methylation and histone modifications have emerged as key mechanisms in
transcriptional regulation. The target of methylation‐induced silencing 1 (TMS1) is a bipartite …

Background Increasing evidence suggests that aberrant methylation is involved in 5-
fluorouracil (5-FU) resistance in gastric cancer (GC). Our previous work has identified that …

The methyl-CpG binding domain (MBD) proteins are key molecules in the interpretation of
DNA methylation signals leading to gene silencing. We investigated their binding specificity …

In the course of gastric cancer development, gene silencing by DNA hypermethylation is an
important mechanism. While DNA methylation often co-exists with histone modifications to …

The identification of molecular pathways in cancer cells is important for understanding the
cells' underlying biology and for designing effective cancer therapies. We demonstrate that …

Taxanes are applied as potent chemotherapeutic agents in the treatment of patients with
esophageal cancer, but their usefulness is limited, partly because of acquisition of …

Despite the improvement in gastric cancer (GC) treatment, multidrug resistance (MDR) is still
a significant reason for chemotherapy failure. Our previous studies have demonstrated that …

The development of multidrug resistance (MDR) in cancer can severely impede the efficacy
of chemotherapy treatment. P-glycoprotein (Pgp) overexpression, encoded by the MDR1 …