SIRT1 and aging related signaling pathways
C Chen, M Zhou, Y Ge, X Wang - Mechanisms of ageing and development, 2020 - Elsevier
Aging is a biological phenomenon in which the structure and function of organisms declining
with the increasing of age. It has become a major risk factor of human diseases, including …
with the increasing of age. It has become a major risk factor of human diseases, including …
Where metabolism meets senescence: focus on endothelial cells
Despite the decline in their proliferative potential, senescent cells display a high metabolic
activity. Senescent cells have been shown to acquire a more glycolytic state even in …
activity. Senescent cells have been shown to acquire a more glycolytic state even in …
Antiaging agents: Safe interventions to slow aging and healthy life span extension
JK Liu - Natural Products and Bioprospecting, 2022 - Springer
Human longevity has increased dramatically during the past century. More than 20% of the 9
billion population of the world will exceed the age of 60 in 2050. Since the last three …
billion population of the world will exceed the age of 60 in 2050. Since the last three …
Therapeutic potential of quercetin to alleviate endothelial dysfunction in age-related cardiovascular diseases
O Dagher, P Mury, N Thorin-Trescases… - Frontiers in …, 2021 - frontiersin.org
The vascular endothelium occupies a catalog of functions that contribute to the homeostasis
of the cardiovascular system. It is a physically active barrier between circulating blood and …
of the cardiovascular system. It is a physically active barrier between circulating blood and …
A comprehensive review of Sirtuins: With a major focus on redox homeostasis and metabolism
S Shahgaldi, FR Kahmini - Life Sciences, 2021 - Elsevier
Sirtuins are Class III protein deacetylases with seven conserved isoforms. In general,
Sirtuins are highly activated under cellular stress conditions in which NAD+ levels are …
Sirtuins are highly activated under cellular stress conditions in which NAD+ levels are …
Advances in plant polysaccharides as antiaging agents: Effects and signaling mechanisms
Aging refers to the gradual physiological changes that occur in an organism after reaching
adulthood, resulting in senescence and a decline in biological functions, ultimately leading …
adulthood, resulting in senescence and a decline in biological functions, ultimately leading …
Molecular mechanisms contributing to mesenchymal stromal cell aging
Mesenchymal stem/stromal cells (MSCs) are a reservoir for tissue homeostasis and repair
that age during organismal aging. Beside the fundamental in vivo role of MSCs, they have …
that age during organismal aging. Beside the fundamental in vivo role of MSCs, they have …
Polyphenols as caloric-restriction mimetics and autophagy inducers in aging research
It has been thought that caloric restriction favors longevity and healthy aging where
autophagy plays a vital role. However, autophagy decreases during aging and that can lead …
autophagy plays a vital role. However, autophagy decreases during aging and that can lead …
Targeting Sirtuin1 to treat aging-related tissue fibrosis: From prevention to therapy
X Han, C Ding, XN Sang, MY Peng, Q Yang… - Pharmacology & …, 2022 - Elsevier
Fibrosis, which is characterized by excessive extracellular matrix (ECM) deposition, is a
wound-healing response to organ injury and may promote cancer and failure in various …
wound-healing response to organ injury and may promote cancer and failure in various …
Relieving cellular energy stress in aging, neurodegenerative, and metabolic diseases, SIRT1 as a therapeutic and promising node
Y Fang, X Wang, D Yang, Y Lu, G Wei, W Yu… - Frontiers in Aging …, 2021 - frontiersin.org
The intracellular energy state will alter under the influence of physiological or pathological
stimuli. In response to this change, cells usually mobilize various molecules and their …
stimuli. In response to this change, cells usually mobilize various molecules and their …