Gene delivery of antiviral therapeutics to anatomical sites where viruses accumulate and
persist is a promising approach for the next generation of antiviral therapies. Recombinant …

Biodistribution of self-complementary adeno-associated virus-9 (scAAV9)–chicken β-actin
promoter–green fluorescent protein (GFP) was assessed in juvenile cynomolgus macaques …

Intestinal ischemia/reperfusion (I/R) injury is a typical pathological course in the clinic with a
high morbidity rate. Recent research has pointed out the critical role of ubiquitination during …

Gene therapy offers great promise in addressing neuropathologies associated with the
central and peripheral nervous systems (CNS and PNS). However, genetic access remains …

Objective GM2 gangliosidosis is usually fatal by 5 years of age in its 2 major subtypes, Tay‐
Sachs and Sandhoff disease. First reported in 1881, GM2 gangliosidosis has no effective …

Introduction: There are limited effective therapies available for improving gastrointestinal (GI)
transit in mammals with intractable or chronic constipation. Current therapeutics to improve …

Background Gastroparesis is defined by delayed gastric emptying (GE) without obstruction.
Studies suggest targeting heme oxygenase‐1 (HO1) may ameliorate diabetic gastroparesis …

Introduction Alterations in the composition and function of the gut microbiome have been
reported in idiopathic epilepsy (IE), however, interactions of gut microbes with the enteric …

Background Viral vector technology, especially recombinant adeno-associated virus vector
(rAAV) technology, has shown great promise in preclinical research for clinical applications …

Systemic delivery of adeno-associated virus (AAV) vectors transduces the enteric nervous
system. However, less is known on the mapping and morphological and neurochemical …