Tyrosine kinases are known to play a role in tumour growth and proliferation, and they have
become common drug targets. Tyrosine kinase inhibitors (TKIs) prohibit associated kinases …

Background: Epidermal growth factor receptor tyrosine kinase inhibitors (EGFR-TKIs) is
revolutionizing the management of brain metastases (BMs). This study was to explore the …

Background Central nervous system (CNS) metastases represent a significant source of
morbidity and mortality for patients with ALK tyrosine kinase gene (ALK)-positive NSCLC …

OBJECTIVE Whether combined radiation and tyrosine kinase inhibitor (TKI) therapy in non–
small cell lung cancer (NSCLC) patients with brain metastases (BMs) and epidermal growth …

This study analyzed the differences in subtypes and characteristics of advanced lung
adenocarcinoma (LUAD) patients based on the pentose phosphate metabolic pathway …

Herein, four novel 4-arylaminoquinazoline derivatives with N, N-diethyl (aminoethyl) amino
moiety were designed, synthesised and evaluated on biological activities in vitro. All …

Рак лёгкого (РЛ) является самым частым онкологическим заболеванием. Возможности
лечения РЛ в значительной мере зависят от того, вызв н ли опухоль курением или её …

GATA3 is a transcription factor, known to regulate the transcriptional network and several
pathways using two zinc fingers. Its mutation is associated with a higher risk of breast …

Alteration of methylation is a process seen across a wide variety of species ranging from
bacterial microorganisms to mammals, defined as the adaptation method the organism …

Research on brain metastases kept innovating. We aimed to illustrate what topics the
research focused on and how it varied in different periods of all the studies on brain …