Tuberculosis (TB) is a possible complication of solid organ and hematopoietic stem cell
transplantation. The identification of candidates for preventive chemotherapy is an effective …

In drug development, there are typically a series of preclinical studies that must be
completed with new compounds or regimens before use in humans. A sequence of in vitro …

Background Early-phase and preclinical studies suggest that moxifloxacin-containing
regimens could allow for effective 4-month treatment of uncomplicated, smear-positive …

Tuberculosis is the leading infectious disease responsible for an estimated one and a half
million human deaths each year around the globe. HIV-TB coinfection and rapid increase in …

Recent estimates indicate that tuberculosis (TB) is the leading cause of death worldwide,
alongside the human immunodeficiency virus (HIV) infection. The current treatment is …

In search of new active molecules against Mycobacterium tuberculosis (MTB) H37Ra and M.
bovis BCG, a small focused library of benzothiazinone based 1, 2, 3-triazoles has been …

Background Tuberculosis causes more deaths than any other infectious disease worldwide,
with pulmonary tuberculosis being the most common form. Standard first‐line treatment for …

TB is an infectious disease that is far from being eradicated and controlled. The treatment for
TB is associated with noncompliance to therapy because it consists of a long-term treatment …

A new series of new diphenylamine containing 1, 2, 4-triazoles were synthesized from 4-
arylideneamino-5-[2-(2, 6-dichlorophenylamino) benzyl]-2H-1, 2, 4-triazole-3 (4H)-thiones …

We report herein the synthesis and antimycobacterial activity of 1, 2, 3-triazole derivatives of
isoniazid. Most of the compounds exhibited potent activity against Mycobacterium …