Excessive inflammation is becoming accepted as a critical factor in many human diseases,
including inflammatory and autoimmune disorders, neurodegenerative conditions, infection …

High mobility group box 1 (HMGB1) protein, originally described as a DNA-binding protein
that stabilizes nucleosomes and facilitates transcription, can also be released extracellularly …

The epidermal growth factor receptor (EGFR) signaling pathway is one of the most important
pathways that regulate growth, survival, proliferation, and differentiation in mammalian cells …

The Rho GTPases form a subgroup of the Ras superfamily of 20-to 30-kD GTP-binding
proteins that have been shown to regulate a wide spectrum of cellular functions. These …

Publisher Summary The chapter introduces the mitogen-activated protein (MAP) kinase
(MAPK) module. The identification of MAP kinase pathways exemplifies the power of …

Signal transduction networks allow cells to perceive changes in the extracellular
environment and to mount an appropriate response. Mitogen-activated protein kinase …

The thermogenic activity of brown adipose tissue (BAT) and browning of white adipose
tissue are important components of energy expenditure. Here we show that GPR120, a …

The c-Jun NH2-terminal kinase (JNK) is activated when cells are exposed to environmental
stress, including UV radiation. Gene disruption studies demonstrate that JNK is essential for …

Mitogen-activated protein (MAP) kinases are proline-directed serine/threonine kinases that
are activated by dual phosphorylation on threonine and tyrosine residues in response to a …

We have identified two compounds that inhibit the expression of endothelial-leukocyte
adhesion molecules intercellular adhesion molecule-1, vascular cell adhesion molecule-1 …