Portal hypertension (PHT) is responsible for the more severe and often lethal complications
of cirrhosis such as bleeding oesophageal varices, ascites, renal dysfunction and hepatic …

Nitric oxide (NO) has diverse physiological and pathophysiological effects. The roles of NO
in the renal and cardiac dysfunction found in cirrhosis are reviewed. In the kidneys of …

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the most trusted reference worldwide. Covering both basic science and recent clinical …

In cirrhotic livers, decreased nitric oxide (NO) bioavailability is a major factor increasing
intrahepatic vascular tone. In several vascular disorders, an increase in superoxide (O2−) …

Abstract α-lipoic acid (α-LA) is an antioxidant used for the treatment of a variety of diseases,
including liver cirrhosis, heavy metal poisoining, and diabetic polyneuropathy. In addition to …

The induction of experimental obstructive cholestasis is a reliable model for cholestatic liver
diseases in rodents. Bile duct ligation (BDL) in mice provokes typical time-dependent …

The activation of Kupffer cells represents a central mechanism of inflammatory liver injury
involving the production of two important inflammatory mediators, nitric oxide and TNF‐α …

In carbon tetrachloride-induced liver cirrhosis, diminution of hepatic endothelial nitric oxide
synthase (eNOS) activity may contribute to impaired hepatic vasodilation and portal …

In liver resection and transplantation ischemia-reperfusion injury (IRI) is one of the main
causes of organ dys-or nonfunction. The aim of the present study was to determine whether …

Increased deposition of the extracellular matrix components, particularly collagen, is a
central phenomenon in liver fibrosis. Stellate cells, the central mediators in the pathogenesis …