Cannabis and related compounds have created significant research interest as a promising
therapy in many disorders. However, the individual therapeutic effects of cannabinoids and …

Immunosuppressant drugs (ISDs) are routinely used in clinical practice to maintain organ
transplant survival. However, these drugs are characterized by a restricted therapeutic …

Transporters are large membrane proteins, which control the passage of various
compounds through biological membranes. These proteins are divided into uptake and …

Kidney transplantation is the preferred therapeutic option for end-stage kidney disease, but,
despite major therapeutic advancements, allograft rejection continues to endanger graft …

P-glycoprotein (P-gp) is a crucial membrane transporter situated on the cell's apical surface,
being responsible for eliminating xenobiotics and endobiotics. P-gp modulators are …

Clinical outcomes after organ transplantation have greatly improved in the past 2 decades
with the discovery and development of immunosuppressive drugs such as calcineurin …

Organ transplant is often the treatment of choice as it extends and improves patient life.
Immunosuppressive treatment, which prevents acute rejection of the organ, is used in …

Background Self-assembling peptide scaffolds have been extensively applied in tissue
engineering. Many investigations have modified self-assembling peptide scaffolds by …

目的: 了解重庆地区儿童细胞色素氧化酶450 (CYP450) 单核苷酸多态性, 为指导儿童用药提供
支持. 方法: 使用PCR 法检测400 例儿童中CYP2D6 (100C> T), CYP2C9 (1075A> C) …

Background We evaluated the role of CYP3A5, ABCB1 and SXR gene polymorphisms in the
occurrence of acute kidney rejection in a cohort of pediatric renal transplant recipients …