Endothelial cells play an obligatory role in regulating local vascular tone and maintaining
homeostasis in vascular biology. Cell metabolism, converting food to energy in organisms, is …

Context Diabetes causes severe pathological changes to the microvasculature in many
organs and tissues and is at the same time associated with an increased risk of coronary …

Efficient insulin secretion requires a well-functioning pancreatic islet microvasculature. The
dense network of islet capillaries includes the islet pericyte, a cell that has barely been …

Inadequate pancreatic β cell function underlies type 1 and type 2 diabetes mellitus.
Strategies to expand functional cells have focused on discovering and controlling …

Islet gene expression has been widely studied to better understand the transcriptional
features that define a healthy β-cell. Transcriptomes of FACS-purified α-, β-, and δ-cells …

The islets of Langerhans or pancreatic islets are pivotal in the control of blood glucose and
are complex microorgans embedded within the larger volume of the exocrine pancreas …

Obesity and its comorbidities like diabetes, hypertension and other cardiovascular disorders
are the leading causes of death and disability worldwide. Metabolic diseases cause …

Cells in different tissues, including endocrine cells in the pancreas, live in complex
microenvironments that are rich in cellular and acellular components. Intricate interactions …

Human and rodent islets differ substantially in several features, including architecture, cell
composition, gene expression and some aspects of insulin secretion. Mouse pancreatic …

The autonomic nervous system affects glucose metabolism partly through its connection to
the pancreatic islet. Since its discovery by Paul Langerhans, the precise innervation patterns …