Revisiting supersaturation of a biopharmaceutical classification system IIB drug: Evaluation via a multi-cup dissolution approach and molecular dynamic simulation
Y Gan, Y Xu, X Zhang, H Hu, W Xiao, Z Yu, T Sun… - Molecules, 2023 - mdpi.com
As a subclass of the biopharmaceutical classification system (BCS) class II, basic drugs
(BCS IIB) exhibit pH-dependent solubility and tend to generate supersaturation in the …
(BCS IIB) exhibit pH-dependent solubility and tend to generate supersaturation in the …
Solubility-enabling formulations for oral delivery of lipophilic drugs: considering the solubility-permeability interplay for accelerated formulation development
N Fine-Shamir, A Dahan - Expert Opinion on Drug Delivery, 2024 - Taylor & Francis
Introduction Tackling low water solubility of drug candidates is a major challenge in today's
pharmaceutics/biopharmaceutics, especially by means of modern solubility-enabling …
pharmaceutics/biopharmaceutics, especially by means of modern solubility-enabling …
Emerging applications of hydroxypropyl methylcellulose acetate succinate: different aspects in drug delivery and its commercial potential
Hydroxypropyl methylcellulose acetate succinate (HPMCAS) has multi-disciplinary
applications spanning across the development of drug delivery systems, in 3D printing, and …
applications spanning across the development of drug delivery systems, in 3D printing, and …
Model-Informed Drug Development: In Silico Assessment of Drug Bioperformance following Oral and Percutaneous Administration
J Djuris, S Cvijic, L Djekic - Pharmaceuticals, 2024 - mdpi.com
The pharmaceutical industry has faced significant changes in recent years, primarily
influenced by regulatory standards, market competition, and the need to accelerate drug …
influenced by regulatory standards, market competition, and the need to accelerate drug …
Physicochemical Characterization of Hydroxyapatite Hybrids with Meloxicam for Dissolution Rate Improvement
Organic–inorganic hybrids represent a good solution to improve the solubility and
dissolution rates of poorly soluble drugs whose number has been increasing in the last few …
dissolution rates of poorly soluble drugs whose number has been increasing in the last few …
Enhanced dissolution of curcumin-resorcinol cocrystal by the inhibition effect of HPMCAS on solution-mediated phase transformation
W Wang, J Lu, A Dai, L Shang, M Chen… - Journal of Molecular …, 2024 - Elsevier
The present study aimed to investigate the inhibition effect of polymers on the solution-
mediated phase transformation (SMPT) of cocrystals during dissolution. Curcumin-resorcinol …
mediated phase transformation (SMPT) of cocrystals during dissolution. Curcumin-resorcinol …
Supersaturation Behavior: Investigation of Polymers Impact on Nucleation Kinetic Profile for Rationalizing the Polymeric Precipitation Inhibitors
Background: Although nucleation kinetic data is quite important for the concept of
supersaturation behavior, its part in rationalizing the crystallization inhibitor has not been …
supersaturation behavior, its part in rationalizing the crystallization inhibitor has not been …
Polymer-mediated solubility enhancement and supersaturation stabilization using various hydroxypropyl cellulose grades within amorphous solid dispersions
F Pöstges - 2024 - bonndoc.ulb.uni-bonn.de
Solubility enhancement in combination with supersaturation stabilization of poorly soluble
drugs is a well-established concept to enhance oral bioavailability. One promising …
drugs is a well-established concept to enhance oral bioavailability. One promising …
Biopharmaceutical characterization and formulation development of poorly water-soluble phytochemicals using in vivo predictive biphasic dissolution
MB Brenner - 2024 - bonndoc.ulb.uni-bonn.de
Nature offers a vast variety of different substances, some of which are known to have health-
beneficial effects on humans. Thus, many of these compounds are frequently used as …
beneficial effects on humans. Thus, many of these compounds are frequently used as …