Risk of cardiovascular outcomes in patients with type 2 diabetes after addition of SGLT2 inhibitors versus sulfonylureas to baseline GLP-1RA therapy
Background: Several glucagon-like peptide receptor agonists (GLP-1RA) and sodium-
glucose cotransporter-2 inhibitors (SGLT2i) have demonstrated cardiovascular benefit in …
glucose cotransporter-2 inhibitors (SGLT2i) have demonstrated cardiovascular benefit in …
Development and application of a machine learning approach to assess short-term mortality risk among patients with cancer starting chemotherapy
Importance Patients with cancer who die soon after starting chemotherapy incur costs of
treatment without the benefits. Accurately predicting mortality risk before administering …
treatment without the benefits. Accurately predicting mortality risk before administering …
Predictive modeling of US health care spending in late life
That one-quarter of Medicare spending in the United States occurs in the last year of life is
commonly interpreted as waste. But this interpretation presumes knowledge of who will die …
commonly interpreted as waste. But this interpretation presumes knowledge of who will die …
Perioperative gabapentin use and in-hospital adverse clinical events among older adults after major surgery
Importance Gabapentin has been increasingly used as part of a multimodal analgesia
regimen to reduce opioid use in perioperative pain management. However, the safety of …
regimen to reduce opioid use in perioperative pain management. However, the safety of …
Nonrandomized real‐world evidence to support regulatory decision making: process for a randomized trial replication project
JM Franklin, A Pawar, D Martin… - Clinical …, 2020 - Wiley Online Library
Recent legislation mandates that the US Food and Drug Administration issue guidance
regarding when real‐world evidence (RWE) could be used to support regulatory decision …
regarding when real‐world evidence (RWE) could be used to support regulatory decision …
Diagnosing physician error: A machine learning approach to low-value health care
S Mullainathan, Z Obermeyer - The Quarterly Journal of …, 2022 - academic.oup.com
We use machine learning as a tool to study decision making, focusing specifically on how
physicians diagnose heart attack. An algorithmic model of a patient's probability of heart …
physicians diagnose heart attack. An algorithmic model of a patient's probability of heart …
Association between receipt of a medically tailored meal program and health care use
SA Berkowitz, J Terranova, L Randall… - JAMA internal …, 2019 - jamanetwork.com
Importance Whether interventions to improve food access can reduce health care use is
unknown. Objective To determine whether participation in a medically tailored meal …
unknown. Objective To determine whether participation in a medically tailored meal …
Assessment of cardiovascular risk in older patients with gout initiating febuxostat versus allopurinol: population-based cohort study
MA Zhang, DH Solomon, RJ Desai, EH Kang, J Liu… - Circulation, 2018 - Am Heart Assoc
Background: Hyperuricemia and gout are associated with an increased risk of
cardiovascular disease. Xanthine oxidase inhibitors, allopurinol and febuxostat, are the …
cardiovascular disease. Xanthine oxidase inhibitors, allopurinol and febuxostat, are the …
Sleep, suicide behaviors, and the protective role of sleep medicine
Abstract Objective/Background Sleep disturbance is associated with suicidal thoughts and
behaviors. The relationship of specific sleep disorders to suicide attempts is less well …
behaviors. The relationship of specific sleep disorders to suicide attempts is less well …
Comparative effectiveness of vancomycin and metronidazole for the prevention of recurrence and death in patients with Clostridium difficile infection
VW Stevens, RE Nelson… - JAMA internal …, 2017 - jamanetwork.com
Importance Metronidazole hydrochloride has historically been considered first-line therapy
for patients with mild to moderateClostridium difficileinfection (CDI) but is inferior to …
for patients with mild to moderateClostridium difficileinfection (CDI) but is inferior to …