Importance In patients with heart failure and reduced ejection fraction (HFrEF), treatment
with sacubitril-valsartan reduces N-terminal pro–b-type natriuretic peptide (NT-proBNP) …

To date, five cancer treatment modalities have been defined. The three traditional modalities
of cancer treatment are surgery, radiotherapy, and conventional chemotherapy, and the two …

Abstract Purpose of Review To review reverse cardiac remodeling and guideline-directed
medical and device therapy (GDMT) within the context of recent data on combined …

de Boer RA, van Veldhuisen DJ, Gansevoort RT, Muller Kobold AC, van Gilst WH, Hillege
HL, Bakker SJL, van der Harst P (University of Groningen). The fibrosis marker galectin‐3 …

Cardiac remodeling and inflammation are hallmarks of cardiac failure and correlate with
outcome in patients. However, the basis for the development of both remains unclear. We …

Background Limited data exists regarding biomarker use to predict left ventricular (LV)
reverse remodeling (R2). Our aim was to examine the value of soluble ST2 (ST2), N-terminal …

Heart failure characterized by cardiac remodeling is a global problem. Angiotensin II (Ang II)
induces cardiac inflammation and oxidative stress, which also is implicated in the …

Objectives: This study sought to determine whether specific patterns of adverse left
ventricular (LV) structural remodeling are associated with differential rates of cardiovascular …

Among patients with heart failure with reduced ejection fraction, investigators have
repeatedly identified a subgroup whose left ventricular ejection fraction and structural …

Inflammation has been considered a key component in the pathogenesis and progression of
angiotensin II‐(Ang II‐) induced cardiac hypertrophy and related cardiomyopathy. As a vital …