The contact sites that the endoplasmic reticulum (ER) forms with mitochondria, called
mitochondria-associated membranes (MAMs), are a hot topic in biological research, and …

ABSTRACT Calcium (Ca2+) is a key player in the regulation of many cell functions. Just like
Ca2+, mitochondria are ubiquitous, versatile, and dynamic players in determining both cell …

Type 2 diabetic cardiomyopathy features Ca 2+ signaling abnormalities, notably an altered
mitochondrial Ca 2+ handling. We here aimed to study if it might be due to a dysregulation of …

The close apposition between endoplasmic reticulum (ER) and mitochondria represents a
key platform, capable to regulate different fundamental cellular pathways. Among these, Ca …

The endoplasmic reticulum (ER) and mitochondria are physically connected to form
dedicated structural domains known as mitochondria-associated ER membranes (MAMs) …

The recent discovery of interconnections between the endoplasmic reticulum (ER)
membrane and those of almost all the cell compartments is providing novel perspectives for …

Modifications of the interactions between endoplasmic reticulum (ER) and mitochondria,
defined as mitochondria-associated membranes (MAMs), were recently shown to be …

In addition to their role in providing cellular energy, mitochondria fulfill a key function in
cellular calcium management. The present review provides an integrative view of cellular …

Mitochondrial damage is implicated as a major contributing factor for a number of
noncommunicable chronic diseases such as cardiovascular diseases, cancer, obesity, and …

Repetitive, calcium-mediated contractile activity renders cardiomyocytes critically dependent
on a sustained energy supply and adequate calcium buffering, both of which are provided …