Genomic instability is a primary cause and fundamental feature of human cancer. However,
all cancer cell genotypes generally translate into several common pathophysiological …

Hypoxia-inducible factor 1 alpha (HIF-1α) orchestrates cellular adaptation to low oxygen and
nutrient-deprived environment and drives progression to malignancy in human solid …

Metabolic reprogramming in tumours is now recognized as a hallmark of cancer,
participating both in tumour growth and cancer progression. Cancer cells develop global …

Background Despite integrin being highlighted as a stiffness‐sensor molecule in matrix
stiffness‐driven angiogenesis, other stiffness‐sensor molecules and their mechanosensory …

The interplay between Ca 2+ and reactive oxygen species (ROS) signaling pathways is well
established, with reciprocal regulation occurring at a number of subcellular locations. Many …

Transient receptor potential (TRP) channels are one primary type of calcium (Ca 2+)
permeable channels, and those relevant transmembrane and intracellular TRP channels …

Hypoxia-induced alternative splicing is a potent driving force in tumour pathogenesis and
progression. In this review, we update currents concepts of hypoxia-induced alternative …

Endothelial dysfunction is a major player in the development and progression of vascular
pathology in pulmonary arterial hypertension (PAH), a disease associated with small vessel …

Transient receptor potential melastatin 2 (TRPM2) is a calcium (Ca 2+)-permeable non-
selective cation channel belonging to the TRP ion channel family. Oxidative stress-induced …

The TRP ion channel TRPM2 has an essential function in cell survival and protects the
viability of a number of cell types after oxidative stress. It is highly expressed in many …