Neurodegenerative disorders are characterized by the progressive dysfunction and death of
selectively vulnerable neuronal populations, often associated with the accumulation of …

The NOD-like receptor protein 3 (NLRP3) inflammasome is a protein complex that regulates
innate immune responses by activating caspase-1 and the inflammatory cytokines …

Abstract In the Central Nervous System (CNS), neuroinflammation orchestrated by microglia
and astrocytes is an innate immune response to counteract stressful and dangerous insults …

Neuroinflammation is a key pathological feature in neurological diseases, including
Alzheimer's disease (AD). The nucleotide-binding domain leucine-rich repeat-containing …

Our understanding of the role of innate and adaptive immune cell function in brain health
and how it goes awry during aging and neurodegenerative diseases is still in its infancy …

Central nervous system (CNS) accumulation of fibrillary deposits made of Amyloid β (A β),
hyperphosphorylated Tau or α-synuclein (α-syn), present either alone or in the form of mixed …

Background Parkinson's disease (PD) is the second most common neurodegenerative
disease, and is characterized by accumulation of α-synuclein (α-syn). Neuroinflammation …

Parkinson's disease (PD) is a common neurodegenerative disorder caused by the loss of
dopamine neurons in the substantia nigra and the formation of Lewy bodies, which are …

Microglia are the immune effector cells of the brain playing critical roles in immune
surveillance and neuroprotection in healthy conditions, while they can sustain …

A growing body of evidence demonstrates the important role of the noradrenergic system in
the pathogenesis of many neurodegenerative processes, especially Alzheimer's disease …