Mechanisms and regulation of endothelial VEGF receptor signalling
M Simons, E Gordon, L Claesson-Welsh - Nature reviews Molecular …, 2016 - nature.com
Vascular endothelial growth factors (VEGFs) and their receptors (VEGFRs) are uniquely
required to balance the formation of new blood vessels with the maintenance and …
required to balance the formation of new blood vessels with the maintenance and …
[HTML][HTML] Recent progress on vascular endothelial growth factor receptor inhibitors with dual targeting capabilities for tumor therapy
Y Liu, Y Li, Y Wang, C Lin, D Zhang, J Chen… - Journal of Hematology & …, 2022 - Springer
Vascular endothelial growth factor receptors (VEGFRs) are a family of receptor protein
tyrosine kinases that play an important role in the regulation of tumor-induced angiogenesis …
tyrosine kinases that play an important role in the regulation of tumor-induced angiogenesis …
[HTML][HTML] Molecular pharmacology of VEGF-A isoforms: binding and signalling at VEGFR2
Vascular endothelial growth factor-A (VEGF-A) is a key mediator of angiogenesis, signalling
via the class IV tyrosine kinase receptor family of VEGF Receptors (VEGFRs). Although …
via the class IV tyrosine kinase receptor family of VEGF Receptors (VEGFRs). Although …
[HTML][HTML] Sex differences in cancer mechanisms
JB Rubin, JS Lagas, L Broestl, J Sponagel… - Biology of sex …, 2020 - Springer
We now know that cancer is many different diseases, with great variation even within a
single histological subtype. With the current emphasis on developing personalized …
single histological subtype. With the current emphasis on developing personalized …
[HTML][HTML] A quantitative view on multivalent nanomedicine targeting
Although the concept of selective delivery has been postulated over 100 years ago, no
targeted nanomedicine has been clinically approved so far. Nanoparticles modified with …
targeted nanomedicine has been clinically approved so far. Nanoparticles modified with …
VEGF-induced neoangiogenesis is mediated by NAADP and two-pore channel-2–dependent Ca2+ signaling
A Favia, M Desideri, G Gambara… - Proceedings of the …, 2014 - National Acad Sciences
Vascular endothelial growth factor (VEGF) and its receptors VEGFR1/VEGFR2 play major
roles in controlling angiogenesis, including vascularization of solid tumors. Here we …
roles in controlling angiogenesis, including vascularization of solid tumors. Here we …
VEGFR-2 conformational switch in response to ligand binding
S Sarabipour, K Ballmer-Hofer, K Hristova - Elife, 2016 - elifesciences.org
VEGFR-2 is the primary regulator of angiogenesis, the development of new blood vessels
from pre-existing ones. VEGFR-2 has been hypothesized to be monomeric in the absence of …
from pre-existing ones. VEGFR-2 has been hypothesized to be monomeric in the absence of …
[HTML][HTML] The role of heterodimerization between VEGFR-1 and VEGFR-2 in the regulation of endothelial cell homeostasis
VEGF-A activity is tightly regulated by ligand and receptor availability. Here we investigate
the physiological function of heterodimers between VEGF receptor-1 (VEGFR-1; Flt-1) and …
the physiological function of heterodimers between VEGF receptor-1 (VEGFR-1; Flt-1) and …
[HTML][HTML] VEGFR1 and VEGFR2 involvement in extracellular galectin-1-and galectin-3-induced angiogenesis
N D'Haene, S Sauvage, C Maris, I Adanja… - PloS one, 2013 - journals.plos.org
Aim Accumulating evidence suggests that extracellular galectin-1 and galectin-3 promote
angiogenesis. Increased expression of galectin-1 and/or galectin-3 has been reported to be …
angiogenesis. Increased expression of galectin-1 and/or galectin-3 has been reported to be …
[HTML][HTML] Discovery of high-affinity PDGF-VEGFR interactions: redefining RTK dynamics
Nearly all studies of angiogenesis have focused on uni-family ligand-receptor binding, eg,
VEGFs bind to VEGF receptors, PDGFs bind to PDGF receptors, etc. The discovery of VEGF …
VEGFs bind to VEGF receptors, PDGFs bind to PDGF receptors, etc. The discovery of VEGF …