Infections caused by bacteria are a significant issue on a global scale, and imperative action
is required to discover novel or improved therapeutic agents. Flavonoids are a class of plant …

Urease is a kind of nickel-dependent metalloenzyme, which exists in the biological world
widely, and can catalyse the hydrolysis of urea into ammonia and carbon dioxide to provide …

Gum arabica is a local commercial nutraceutical and food preservative collected mostly from
acacia plants. HPLC-DAD analysis identified gallic acid, syringic acid, ferulic acid, coumarin …

Catechols have been reported to be potent covalent inhibitors of ureases, and they exhibit
activity by modifying cysteine residues at the entrance to enzymatic active sites. Following …

New series of barbiturates linked to aryl hydrazone derivatives 4a-n were designed and
synthesized. Briefly, aniline derivatives in the presence of HBF4 and NaNO2 convert to aryl …

The current investigation encompasses the structural planning, synthesis, and evaluation of
the urease inhibitory activity of a series of molecular hybrids of hydroxamic acids and …

In this work, a series of chalcones (1a–d, 2a–d, 3a–d, 4a–d, and 5a–d) were designed and
synthesized by Claisen–Schmidt condensation. Also, their chemical structures were …

This study aim to synthesize new 1, 3, 4-oxadiazole derivatives incorporating mefenamic
acid as promising α-glucosidase and urease inhibitors, potentially leading to the treatment of …

epideoxyloganic acid (ELA) was isolated from the aerial parts of endemic Nepeta aristata
Boiss Et Kotschy Ex Boiss crude extract (methanol: chloroform) using silica gel (hexane …

Crystal structures of two closely related N-(adamantan-1-yl) piperazine carbothioamides
have been examined in detail using the Hirshfeld surface, fingerprint analysis, PIXEL energy …