Immunotherapeutic uses of CpG oligodeoxynucleotides
DM Klinman - Nature Reviews Immunology, 2004 - nature.com
Synthetic oligodeoxynucleotides (ODNs) that contain immunostimulatory CpG motifs trigger
an immunomodulatory cascade that involves B and T cells, natural killer cells and …
an immunomodulatory cascade that involves B and T cells, natural killer cells and …
DNA vaccines: immunology, application, and optimization
S Gurunathan, DM Klinman… - Annual review of …, 2000 - annualreviews.org
The development and widespread use of vaccines against infectious agents have been a
great triumph of medical science. One reason for the success of currently available vaccines …
great triumph of medical science. One reason for the success of currently available vaccines …
Cutting edge: role of Toll-like receptor 9 in CpG DNA-induced activation of human cells
Unmethylated CpG motifs present in bacterial DNA stimulate a rapid and robust innate
immune response. Human cell lines and PBMC that recognize CpG DNA express …
immune response. Human cell lines and PBMC that recognize CpG DNA express …
DNA vaccines: a key for inducing long-term cellular immunity
S Gurunathan, CY Wu, BL Freidag, RA Seder - Current opinion in …, 2000 - Elsevier
Over the past few years, major advances in several areas of immunology have provided a
foundation for the rational design of vaccines against diseases requiring cellular immunity …
foundation for the rational design of vaccines against diseases requiring cellular immunity …
Use of CpG oligodeoxynucleotides as immune adjuvants
DM Klinman, D Currie, I Gursel… - Immunological …, 2004 - Wiley Online Library
Synthetic oligodeoxynucleotides (ODNs) containing unmethylated CpG motifs directly
stimulate human B cells and plasmacytoid dendritic cells (pDCs), thereby promoting the …
stimulate human B cells and plasmacytoid dendritic cells (pDCs), thereby promoting the …
Sterically stabilized cationic liposomes improve the uptake and immunostimulatory activity of CpG oligonucleotides
Immunostimulatory CpG oligonucleotides (ODN) show promise as immune adjuvants, anti-
allergens, and immunoprotective agents. Increasing the bioavailability and duration of action …
allergens, and immunoprotective agents. Increasing the bioavailability and duration of action …
Novel vaccine development strategies for inducing mucosal immunity
Y Fukuyama, D Tokuhara, K Kataoka… - Expert review of …, 2012 - Taylor & Francis
To develop protective immune responses against mucosal pathogens, the delivery route
and adjuvants for vaccination are important. The host, however, strives to maintain mucosal …
and adjuvants for vaccination are important. The host, however, strives to maintain mucosal …
CpG oligodeoxynucleotides as vaccine adjuvants in primates
D Verthelyi, RT Kenney, RA Seder, AA Gam… - The journal of …, 2002 - journals.aai.org
Synthetic oligodeoxynucleotides (ODN) containing unmethylated CpG motifs act as immune
adjuvants in mice, boosting the humoral and cellular response to coadministered Ags. CpG …
adjuvants in mice, boosting the humoral and cellular response to coadministered Ags. CpG …
CpG motif identification for veterinary and laboratory species demonstrates that sequence recognition is highly conserved
R Rankin, R Pontarollo, X Ioannou… - … and Nucleic Acid …, 2001 - liebertpub.com
Oligodinucleotides containing CpG motifs stimulate vertebrate immune cells in vitro, have
proven efficacy in murine disease models and are currently being tested in human clinical …
proven efficacy in murine disease models and are currently being tested in human clinical …
Adjuvant activity of CpG oligodeoxynucleotides
DM Klinman - International reviews of immunology, 2006 - Taylor & Francis
Synthetic oligodeoxynucleotides (ODNs) containing unmethylated CpG motifs directly
stimulate human B cells and plasmacytoid dendritic cells (pDCs), thereby promoting the …
stimulate human B cells and plasmacytoid dendritic cells (pDCs), thereby promoting the …