Autism spectrum disorder (ASD) is a pervasive neurodevelopmental disorder characterized
by difficulties in social interaction, language development delays, repeated body …

Rodents emit ultrasonic vocalizations (USVs) to communicate the presence of positive or
negative emotional states and to coordinate social interactions. On this basis, USVs are …

Despite the substantial heritability of antisocial behavior (ASB), specific genetic variants
robustly associated with the trait have not been identified. The present study by the Broad …

FOXP transcription factors are an evolutionarily ancient protein subfamily coordinating the
development of several organ systems in the vertebrate body. Association of their genes …

The discovery of the FOXP2 transcription factor, and its implication in a rare severe human
speech and language disorder, has led to two decades of empirical studies focused on …

Summary Forkhead box P2 (FOXP2) is a transcription factor expressed in the human brain
that peaks during fetal development, and disruption in its ability to regulate downstream …

Highlights•Rare variants disrupting speech, in genes like FOXP2, give insight into
neurobiology of key human traits.•Neural functions of FOXP2 are being studied in human …

Oxytocin (OT) is a prominent regulator of many aspects of mammalian social behavior and
stored in large dense-cored vesicles (LDCVs) in hypothalamic neurons. It is released in …

Attention-deficit/hyperactivity disorder (ADHD) is a highly prevalent neurodevelopmental
disorder resulting from the interaction between genetic and environmental risk factors. It is …

Genetic studies have associated FOXP2 variation with speech and language disorders and
other neurodevelopmental disorders (NDDs) involving pathology of the cortex. In this brain …