High rates of failure, exorbitant costs, and the sluggish pace of new drug discovery and
development have led to a growing interest in repurposing “old” drugs to treat both common …

Recent advancements in modern science have provided robust tools for drug discovery. The
rapid development of transcriptome sequencing technologies has given rise to single-cell …

Simple Summary Breast cancer that has metastasized to other parts of the body still has a
high incidence and mortality rate. Furthermore, treating metastatic breast cancer remains a …

Simple Summary Liver metastasis is a significant factor contributing to mortality associated
with colorectal cancer. Establishing the biological mechanisms of metastasis is crucial for …

The key challenge in cancer treatment is prevention of metastatic disease which is
therapeutically resistant and carries poor prognoses necessitating efficacious prophylactic …

Long non-coding RNAs (lncRNAs) are a diverse class of RNA molecules that do not code for
proteins but play critical roles in gene regulation. One such role involves the modulation of …

Simple Summary Cancer stands as the second leading cause of death globally. Over the
years, concerted efforts have been devoted to developing innovative and effective therapies …

The molecular mechanisms of the liver metastasis of colorectal cancer (CRLM) remain
poorly understood. Here, we applied machine learning and bioinformatics trajectory …

As things stand in 2023, metastatic osteosarcoma commonly results in death. There has
been little treatment progress in recent decades. To redress the poor prognosis of metastatic …

Metastasis and resistance to cancer therapeutics are critical barriers to curing cancer. This
special issue entitled “Cancer Metastasis and Therapeutic Resistance” contains nine …