Cyclodextrins: Emerging medicines of the new millennium

SS Braga - Biomolecules, 2019 - mdpi.com
Cyclodextrins, since their discovery in the late 19th century, were mainly regarded as
excipients. Nevertheless, developments in cyclodextrin research have shown that some of …

Coronavirus interplay with lipid rafts and autophagy unveils promising therapeutic targets

K Fecchi, S Anticoli, D Peruzzu, E Iessi… - Frontiers in …, 2020 - frontiersin.org
Coronaviruses are enveloped, single-stranded, positive-sense RNA viruses that can infect
animal and human hosts. The infection induces mild or sometimes severe acute respiratory …

The Lord of the NanoRings: Cyclodextrins and the battle against SARS-CoV-2

PF Garrido, M Calvelo, A Blanco-Gonzalez… - International journal of …, 2020 - Elsevier
A handful of singular structures and laws can be observed in nature. They are not always
evident but, once discovered, it seems obvious how to take advantage of them. In chemistry …

Ebola virus glycoprotein interacts with cholesterol to enhance membrane fusion and cell entry

J Lee, AJB Kreutzberger, L Odongo, EA Nelson… - Biophysical …, 2021 - cell.com
Cholesterol serves critical roles in enveloped virus fusion by modulating membrane
biophysical properties. The glycoprotein (GP) of Ebola virus (EBOV) promotes fusion in the …

Cyclodextrin monomers and polymers for drug activity enhancement

A Matencio, G Hoti, YK Monfared, A Rezayat… - Polymers, 2021 - mdpi.com
Cyclodextrins (CDs) and cyclodextrin (CD)-based polymers are well-known complexing
agents. One of their distinctive features is to increase the quantity of a drug in a solution or …

Cyclic oligosaccharides as active drugs, an updated review

A Matencio, F Caldera, C Cecone, JM López-Nicolás… - Pharmaceuticals, 2020 - mdpi.com
There have been many reviews of the cyclic oligosaccharide cyclodextrin (CD) and CD-
based materials used for drug delivery, but the capacity of CDs to complex different agents …

Serinc5 restricts HIV membrane fusion by altering lipid order and heterogeneity in the viral membrane

AE Ward, D Sokovikova, MN Waxham… - ACS infectious …, 2023 - ACS Publications
The host restriction factor, Serinc5, incorporates into budding HIV particles and inhibits their
infection by an incompletely understood mechanism. We have previously reported that …

Chewing the fat: the conserved ability of DNA viruses to hijack cellular lipid metabolism

PT Lange, M Lagunoff, VL Tarakanova - Viruses, 2019 - mdpi.com
Viruses manipulate numerous host factors and cellular pathways to facilitate the replication
of viral genomes and the production of infectious progeny. One way in which viruses interact …

AMPK protects endothelial cells against HSV-1 replication via inhibition of mTORC1 and ACC1

H Doshi, K Spengler, A Godbole, YS Gee… - Microbiology …, 2023 - Am Soc Microbiol
Herpes simplex virus type 1 (HSV-1) is a widespread contagious pathogen, mostly causing
mild symptoms on the mucosal entry side. However, systemic distribution, in particular upon …

Apolipoprotein D facilitate the proliferation of BmNPV

S Fei, J Xia, G Ma, M Zhang, J Sun, M Feng… - International Journal of …, 2022 - Elsevier
The silkworm, Bombyx mori, a model Lepidopteran specie, is an important economic insect.
It is specifically infected by Bombyx mori nucleopolyhedrovirus (BmNPV), causing huge …