[HTML][HTML] Stress, epigenetics, and aging: unraveling the intricate crosstalk
Aging, as a complex process involving multiple cellular and molecular pathways, is known to
be exacerbated by various stresses. Because responses to these stresses, such as oxidative …
be exacerbated by various stresses. Because responses to these stresses, such as oxidative …
Gastrointestinal and brain barriers: unlocking gates of communication across the microbiota–gut–brain axis
Crosstalk between gut and brain has long been appreciated in health and disease, and the
gut microbiota is a key player in communication between these two distant organs. Yet, the …
gut microbiota is a key player in communication between these two distant organs. Yet, the …
[HTML][HTML] Strong associations of telomere length and mitochondrial copy number with suicidality and abuse history in adolescent depressed individuals
S Ochi, B Roy, K Prall, RC Shelton, Y Dwivedi - Molecular psychiatry, 2023 - nature.com
Major depressive disorder (MDD) is highly prevalent in adolescents and is a major risk factor
for suicidality. Recent evidence shows that accelerated cellular senescence/aging is …
for suicidality. Recent evidence shows that accelerated cellular senescence/aging is …
Early life stress impairs brain and mental development during childhood increasing the risk of developing psychiatric disorders
N Nakama, N Usui, M Doi, S Shimada - Progress in Neuro …, 2023 - Elsevier
In recent years, it has become known that stress in childhood, called early life stress (ELS),
affects the mental health of children, adolescents, and adults. Child maltreatment (CM) is an …
affects the mental health of children, adolescents, and adults. Child maltreatment (CM) is an …
[HTML][HTML] Potential of circulating miRNAs as molecular markers in mood disorders and associated suicidal behavior
B Roy, S Ochi, Y Dwivedi - International journal of molecular sciences, 2023 - mdpi.com
Mood disorders are the most prevalent psychiatric disorders associated with significant
disability, morbidity, and mortality. The risk of suicide is associated with severe or mixed …
disability, morbidity, and mortality. The risk of suicide is associated with severe or mixed …
Early Life Stress and Major Depressive Disorder—An Update on Molecular Mechanisms and Synaptic Impairments
AG Bertollo, ACL Galvan, C Dallagnol, AD Cortez… - Molecular …, 2024 - Springer
Early life stress (ELS), characterized as abuse, neglect, and abandonment, can cause
several adverse consequences in the lives of affected individuals. ELS experiences can …
several adverse consequences in the lives of affected individuals. ELS experiences can …
[HTML][HTML] Genome–environment interactions and psychiatric disorders
J Peedicayil - Biomedicines, 2023 - mdpi.com
Environmental factors are known to interact with the genome by altering epigenetic
mechanisms regulating gene expression and contributing to the pathogenesis of psychiatric …
mechanisms regulating gene expression and contributing to the pathogenesis of psychiatric …
[HTML][HTML] Vulnerability and resilience to prenatal stress exposure: behavioral and molecular characterization in adolescent rats
Exposure to stress can lead to long lasting behavioral and neurobiological consequences,
which may enhance the susceptibility for the onset of mental disorders. However, there are …
which may enhance the susceptibility for the onset of mental disorders. However, there are …
[HTML][HTML] Lifestyle Factors Counteract the Neurodevelopmental Impact of Genetic Risk for Accelerated Brain Aging in Adolescence
Background The transition from childhood to adolescence is characterized by enhanced
neural plasticity and a consequent susceptibility to both beneficial and adverse aspects of …
neural plasticity and a consequent susceptibility to both beneficial and adverse aspects of …
[HTML][HTML] A role for nNOS in mediating stress and female sexual behavior in mice
K Chachlaki - nature communications, 2024 - nature.com
Developmental stress can detrimentally affect adult female reproductive behavior,
influencing sexual receptivity and fertility. Recent work has demonstrated neuronal nitric …
influencing sexual receptivity and fertility. Recent work has demonstrated neuronal nitric …