The language of chromatin modification in human cancers
The genetic information of human cells is stored in the context of chromatin, which is
subjected to DNA methylation and various histone modifications. Such a 'language'of …
subjected to DNA methylation and various histone modifications. Such a 'language'of …
COMPASS and SWI/SNF complexes in development and disease
BK Cenik, A Shilatifard - Nature Reviews Genetics, 2021 - nature.com
Abstract The Trithorax group (TrxG) of proteins is a large family of epigenetic regulators that
form multiprotein complexes to counteract repressive developmental gene expression …
form multiprotein complexes to counteract repressive developmental gene expression …
Molecular subtypes of diffuse large B cell lymphoma are associated with distinct pathogenic mechanisms and outcomes
Diffuse large B cell lymphoma (DLBCL), the most common lymphoid malignancy in adults, is
a clinically and genetically heterogeneous disease that is further classified into …
a clinically and genetically heterogeneous disease that is further classified into …
Histone H1 loss drives lymphoma by disrupting 3D chromatin architecture
N Yusufova, A Kloetgen, M Teater, A Osunsade… - Nature, 2021 - nature.com
Linker histone H1 proteins bind to nucleosomes and facilitate chromatin compaction,
although their biological functions are poorly understood. Mutations in the genes that …
although their biological functions are poorly understood. Mutations in the genes that …
Double-hit gene expression signature defines a distinct subgroup of germinal center B-cell-like diffuse large B-cell lymphoma
D Ennishi, A Jiang, M Boyle, B Collinge… - Journal of Clinical …, 2019 - ascopubs.org
Purpose High-grade B-cell lymphoma with MYC and BCL2 and/or BCL6 rearrangements
(HGBL-DH/TH) has a poor outcome after standard chemoimmunotherapy. We sought to …
(HGBL-DH/TH) has a poor outcome after standard chemoimmunotherapy. We sought to …
Follicular lymphoma
A Carbone, S Roulland, A Gloghini, A Younes… - Nature reviews Disease …, 2019 - nature.com
Follicular lymphoma (FL) is a systemic neoplasm of the lymphoid tissue displaying germinal
centre (GC) B cell differentiation. FL represents~ 5% of all haematological neoplasms and …
centre (GC) B cell differentiation. FL represents~ 5% of all haematological neoplasms and …
Molecular and genetic characterization of MHC deficiency identifies EZH2 as therapeutic target for enhancing immune recognition
D Ennishi, K Takata, W Béguelin, G Duns, A Mottok… - Cancer discovery, 2019 - AACR
We performed a genomic, transcriptomic, and immunophenotypic study of 347 patients with
diffuse large B-cell lymphoma (DLBCL) to uncover the molecular basis underlying acquired …
diffuse large B-cell lymphoma (DLBCL) to uncover the molecular basis underlying acquired …
Epigenetic balance of gene expression by Polycomb and COMPASS families
A Piunti, A Shilatifard - Science, 2016 - science.org
BACKGROUND Multicellular organisms depend on the precise orchestration of gene
expression to direct embryonic development and to maintain tissue homeostasis through …
expression to direct embryonic development and to maintain tissue homeostasis through …
CREBBP/EP300 mutations promoted tumor progression in diffuse large B-cell lymphoma through altering tumor-associated macrophage polarization via FBXW7 …
YH Huang, K Cai, PP Xu, L Wang, CX Huang… - … and Targeted Therapy, 2021 - nature.com
Epigenetic alterations play an important role in tumor progression of diffuse large B-cell
lymphoma (DLBCL). However, the biological relevance of epigenetic gene mutations on …
lymphoma (DLBCL). However, the biological relevance of epigenetic gene mutations on …
Molecular high-grade B-cell lymphoma: defining a poor-risk group that requires different approaches to therapy
Purpose Biologic heterogeneity is a feature of diffuse large B-cell lymphoma (DLBCL), and
the existence of a subgroup with poor prognosis and phenotypic proximity to Burkitt …
the existence of a subgroup with poor prognosis and phenotypic proximity to Burkitt …