Mutations of ASXL1, encoding a component of the BAP1 histone H2A deubiquitinase
complex, occur in human myeloid neoplasms and are uniformly associated with poor …

During development, precise spatiotemporal patterns of gene expression are coordinately
controlled by cis-regulatory modules known as enhancers. Their crucial role in development …

The Janus kinase (JAK)/signal transducer and activator of transcription (STAT) pathway is a
key intracellular mediator of a variety of metabolically relevant hormones and cytokines …

The oncogenic events involved in breast implant–associated anaplastic large cell lymphoma
(BI-ALCL) remain elusive. To clarify this point, we have characterized the genomic …

Abnormalities in epigenetic modifiers are emerging as driving events in prostate cancer
(PCa). The histone methyltransferase KMT2D, a frequently aberrant epigenetic modifier in …

Background Tumor-associated macrophages (TAMs) secreting IL-10 could be a specific
functional cell subset with distinct polarization state and suppressive role in antitumor …

Hematopoiesis requires finely tuned regulation of gene expression at each stage of
development. The regulation of gene transcription involves not only individual transcription …

Follicular lymphoma (FL) is an incurable B-cell malignancy characterized by advanced
stage disease and a heterogeneous clinical course, with high-risk groups including those …

Intrahepatic cholangiocarcinoma (ICC) is a relatively rare but highly aggressive tumor type
that responds poorly to chemotherapy and immunotherapy. Comprehensive molecular …

The incidence of liver cancer has increased in recent years. Worldwide, liver cancer is
common: more than 600000 related deaths are estimated each year. In the USA, about …