Frequently mutated genes/pathways and genomic instability as prevention targets in liver cancer
The incidence of liver cancer has increased in recent years. Worldwide, liver cancer is
common: more than 600000 related deaths are estimated each year. In the USA, about …
common: more than 600000 related deaths are estimated each year. In the USA, about …
Genomic profiling reveals spatial intra-tumor heterogeneity in follicular lymphoma
S Araf, J Wang, K Korfi, C Pangault, E Kotsiou… - Leukemia, 2018 - nature.com
Follicular lymphoma (FL) is an incurable B-cell malignancy characterized by advanced
stage disease and a heterogeneous clinical course, with high-risk groups including those …
stage disease and a heterogeneous clinical course, with high-risk groups including those …
The immunology of DLBCL
T Takahara, S Nakamura, T Tsuzuki, A Satou - Cancers, 2023 - mdpi.com
Simple Summary Diffuse large B-cell lymphoma (DLBCL) is the most common type of
malignant lymphoid neoplasm and includes morphologically and molecularly …
malignant lymphoid neoplasm and includes morphologically and molecularly …
Molecular subgroups of intrahepatic cholangiocarcinoma discovered by single-cell RNA sequencing–assisted multiomics analysis
X Bao, Q Li, J Chen, D Chen, C Ye, X Dai… - Cancer Immunology …, 2022 - AACR
Intrahepatic cholangiocarcinoma (ICC) is a relatively rare but highly aggressive tumor type
that responds poorly to chemotherapy and immunotherapy. Comprehensive molecular …
that responds poorly to chemotherapy and immunotherapy. Comprehensive molecular …
Epigenetic targeted therapy of stabilized BAP1 in ASXL1 gain-of-function mutated leukemia
Mutations of ASXL1, encoding a component of the BAP1 histone H2A deubiquitinase
complex, occur in human myeloid neoplasms and are uniformly associated with poor …
complex, occur in human myeloid neoplasms and are uniformly associated with poor …
Tracing founder mutations in circulating and tissue-resident follicular lymphoma precursors
Follicular lymphomas (FL) are characterized by BCL2 translocations, often detectable in
blood years before FL diagnosis, but also observed in aging healthy individuals, suggesting …
blood years before FL diagnosis, but also observed in aging healthy individuals, suggesting …
Genome-wide analysis of pediatric-type follicular lymphoma reveals low genetic complexity and recurrent alterations of TNFRSF14 gene
J Schmidt, S Gong, T Marafioti, B Mankel… - Blood, The Journal …, 2016 - ashpublications.org
Pediatric-type follicular lymphoma (PTFL) is a variant of follicular lymphoma (FL) with
distinctive clinicopathological features. Patients are predominantly young males presenting …
distinctive clinicopathological features. Patients are predominantly young males presenting …
MED12 regulates HSC-specific enhancers independently of mediator kinase activity to control hematopoiesis
B Aranda-Orgilles, R Saldaña-Meyer, E Wang… - Cell stem cell, 2016 - cell.com
Hematopoietic-specific transcription factors require coactivators to communicate with the
general transcription machinery and establish transcriptional programs that maintain …
general transcription machinery and establish transcriptional programs that maintain …
Molecular pathogenesis of germinal center‐derived B cell lymphomas
L Pasqualucci - Immunological reviews, 2019 - Wiley Online Library
B cell lymphomas comprise a heterogeneous group of genetically, biologically, and clinically
distinct neoplasms that, in most cases, originate from the clonal expansion of B cells in the …
distinct neoplasms that, in most cases, originate from the clonal expansion of B cells in the …
Autoimmune cytopenias in chronic lymphocytic leukemia: focus on molecular aspects
B Fattizzo, W Barcellini - Frontiers in Oncology, 2020 - frontiersin.org
Autoimmune cytopenias, particularly autoimmune hemolytic anemia (AIHA) and immune
thrombocytopenia (ITP), complicate up to 25% of chronic lymphocytic leukemia (CLL) cases …
thrombocytopenia (ITP), complicate up to 25% of chronic lymphocytic leukemia (CLL) cases …