High-altitude illnesses (HAIs) result from acute exposure to high altitude/hypoxia. Numerous
molecular mechanisms affect appropriate acclimatization to hypobaric and/or normobaric …

Globally, about 400 million people reside at terrestrial altitudes above 1500 m, and more
than 100 million lowlanders visit mountainous areas above 2500 m annually. The …

Immune outcomes are key mediators of many health benefits of exercise and are
determined by exercise type, dose (frequency/duration, intensity), and individual …

Purpose Main purposes of pre-acclimatization by hypoxia conditioning (HC) are the
prevention of high-altitude illnesses and maintenance of aerobic exercise performance …

The (patho-) physiological responses to hypoxia are highly heterogeneous between
individuals. In this review, we focused on the roles of sex differences, which emerge as …

Various strategies can be employed to prevent and manage altitude illnesses, including
habituation, oxygenation, nutritional support, and medication. Nevertheless, the utilization of …

High altitude illness in its most severe form can lead to high altitude cerebral edema
(HACE). Current strategies have focused on prevention with graduated ascents …

Maximal values of aerobic power (VO2max) and peripheral oxygen saturation (SpO2max)
decline in parallel with gain in altitude. Whereas this relationship has been well investigated …

More than 50% of the people worldwide who travel from areas of low elevation to areas over
3500 m in altitude suffer from high-altitude sickness, especially from a decline in sleep …

Millions of people visit high-altitude regions annually and more than 80 million live
permanently above 2,500 m. Acute high-altitude exposure can trigger high-altitude illnesses …