Summary Type 1 diabetes (T1D) is widely considered to result from the autoimmune
destruction of insulin-producing β cells. This concept has been a central tenet for decades of …

The sympathetic nervous system maintains metabolic homeostasis by orchestrating the
activity of organs such as the pancreas, liver, and white and brown adipose tissues. From …

Increasing evidence demonstrated that the expression of Angiotensin I-Converting Enzyme
type 2 (ACE2) is a necessary step for SARS-CoV-2 infection permissiveness. In light of the …

Brain pericytes and vascular smooth muscle cells (vSMCs) are a critical component of the
neurovascular unit and are important in regulating cerebral blood flow and blood-brain …

Islet transplantation is a promising treatment for type 1 diabetes (T1D), yet the low donor
pool, poor islet engraftment, and life-long immunosuppression prevent it from becoming the …

The pancreatic islet is a complex mini organ composed of a variety of endocrine cells and
their support cells, which together tightly control blood glucose homeostasis. Changes in …

Pancreatic islet beta cells are essential for maintaining glucose homeostasis. To understand
the impact of aging on beta cells, we performed meta-analysis of single-cell RNA …

This review focuses on the human pancreatic islet—including its structure, cell composition,
development, function, and dysfunction. After providing a historical timeline of key …

Pancreatic beta cells are the only cell type in our body capable of producing and secreting
insulin to instruct the insulin-sensitive cells and tissues of our bodies to absorb nutrients after …

Background: Microvascular damage from large artery stiffness (LAS) in pancreatic, hepatic,
and skeletal muscles may affect glucose homeostasis. Our goal was to evaluate the …