Macrophages exist in various tissues, several body cavities, and around mucosal surfaces
and are a vital part of the innate immune system for host defense against many pathogens …

Acute kidney injury (AKI) is a growing global health concern, yet no treatment is currently
available to prevent it or to promote kidney repair after injury. Animal models demonstrate …

Legumain is required for maintenance of normal kidney homeostasis. However, its role in
acute kidney injury (AKI) is still unclear. Here, we induced AKI by bilateral ischemia …

Patients with acute kidney injury (AKI) frequently require kidney transplantation and
supportive therapies, such as rehydration and dialysis. Here, we show that radiolabelled …

The development of drugs with rapid distribution in the kidney and long-term retention in the
renal tubule is a breakthrough for enhanced treatment of acute kidney injury (AKI). Here, l …

Acute kidney injury (AKI) is defined by a sudden loss of excretory kidney function. AKI is part
of a range of conditions summarized as acute kidney diseases and disorders (AKD), in …

Calcium overload is one of the early determinants of the core cellular events that contribute
to the pathogenesis of acute kidney injury (AKI), which include oxidative stress, ATP …

Abstract The theme of World Kidney Day 2017 is' kidney disease and obesity: healthy
lifestyle for healthy kidneys'. To mark this event, Nature Reviews Nephrology invited five …

The acute loss of kidney function has been diagnosed for many decades using the serum
concentration of creatinine—a muscle metabolite that is an insensitive and non-specific …

Crystals can trigger a wide range of kidney injuries that can lead to acute kidney injury,
chronic kidney disease, renal colic or nephrocalcinosis, depending on the localization and …