The physiology, pathology, and pharmacology of voltage-gated calcium channels and their future therapeutic potential

GW Zamponi, J Striessnig, A Koschak… - Pharmacological …, 2015 - ASPET
Voltage-gated calcium channels are required for many key functions in the body. In this
review, the different subtypes of voltage-gated calcium channels are described and their …

Etiology and pharmacology of neuropathic pain

SRA Alles, PA Smith - Pharmacological reviews, 2018 - ASPET
Injury to or disease of the nervous system can invoke chronic and sometimes intractable
neuropathic pain. Many parallel, interdependent, and time-dependent processes, including …

[HTML][HTML] SARS-CoV-2 spike protein co-opts VEGF-A/neuropilin-1 receptor signaling to induce analgesia

A Moutal, LF Martin, L Boinon, K Gomez, D Ran… - Pain, 2021 - journals.lww.com
SARS-CoV-2 spike protein co-opts VEGF-A/neuropilin-1 recepto... : PAIN SARS-CoV-2 spike
protein co-opts VEGF-A/neuropilin-1 receptor signaling to induce analgesia : PAIN …

Bio‐Inspired 3D Artificial Neuromorphic Circuits

X Liu, F Wang, J Su, Y Zhou… - Advanced Functional …, 2022 - Wiley Online Library
Neuromorphic circuits emulating the bio‐brain functionality via artificial devices have
achieved a substantial scientific leap in the past decade. However, even with the advent of …

Studying human nociceptors: from fundamentals to clinic

SJ Middleton, AM Barry, M Comini, Y Li, PR Ray… - Brain, 2021 - academic.oup.com
Chronic pain affects one in five of the general population and is the third most important
cause of disability-adjusted life-years globally. Unfortunately, treatment remains inadequate …

[HTML][HTML] Human dorsal root ganglia

RV Haberberger, C Barry, N Dominguez… - Frontiers in cellular …, 2019 - frontiersin.org
Sensory neurons with cell bodies situated in dorsal root ganglia convey information from
external or internal sites of the body such as actual or potential harm, temperature or muscle …

[HTML][HTML] Deep sequencing of somatosensory neurons reveals molecular determinants of intrinsic physiological properties

Y Zheng, P Liu, L Bai, JS Trimmer, BP Bean, DD Ginty - Neuron, 2019 - cell.com
Dorsal root ganglion (DRG) sensory neuron subtypes defined by their in vivo properties
display distinct intrinsic electrical properties. We used bulk RNA sequencing of genetically …

Targeting voltage-gated calcium channels in neurological and psychiatric diseases

GW Zamponi - Nature reviews Drug discovery, 2016 - nature.com
Voltage-gated calcium channels are important regulators of brain, heart and muscle
functions, and their dysfunction can give rise to pathophysiological conditions ranging from …

Quantitative differences in neuronal subpopulations between mouse and human dorsal root ganglia demonstrated with RNAscope in situ hybridization

S Shiers, RM Klein, TJ Price - Pain, 2020 - journals.lww.com
Next-generation transcriptomics in combination with imaging-based approaches have
emerged as powerful tools for the characterization of dorsal root ganglion (DRG) neuronal …

[HTML][HTML] Mechanisms of osteoarthritic pain. Studies in humans and experimental models

A Eitner, GO Hofmann, HG Schaible - Frontiers in molecular …, 2017 - frontiersin.org
Pain due to osteoarthritis (OA) is one of the most frequent causes of chronic pain. However,
the mechanisms of OA pain are poorly understood. This review addresses the mechanisms …