The physiology, pathology, and pharmacology of voltage-gated calcium channels and their future therapeutic potential
GW Zamponi, J Striessnig, A Koschak… - Pharmacological …, 2015 - ASPET
Voltage-gated calcium channels are required for many key functions in the body. In this
review, the different subtypes of voltage-gated calcium channels are described and their …
review, the different subtypes of voltage-gated calcium channels are described and their …
Etiology and pharmacology of neuropathic pain
SRA Alles, PA Smith - Pharmacological reviews, 2018 - ASPET
Injury to or disease of the nervous system can invoke chronic and sometimes intractable
neuropathic pain. Many parallel, interdependent, and time-dependent processes, including …
neuropathic pain. Many parallel, interdependent, and time-dependent processes, including …
[HTML][HTML] SARS-CoV-2 spike protein co-opts VEGF-A/neuropilin-1 receptor signaling to induce analgesia
SARS-CoV-2 spike protein co-opts VEGF-A/neuropilin-1 recepto... : PAIN SARS-CoV-2 spike
protein co-opts VEGF-A/neuropilin-1 receptor signaling to induce analgesia : PAIN …
protein co-opts VEGF-A/neuropilin-1 receptor signaling to induce analgesia : PAIN …
Bio‐Inspired 3D Artificial Neuromorphic Circuits
X Liu, F Wang, J Su, Y Zhou… - Advanced Functional …, 2022 - Wiley Online Library
Neuromorphic circuits emulating the bio‐brain functionality via artificial devices have
achieved a substantial scientific leap in the past decade. However, even with the advent of …
achieved a substantial scientific leap in the past decade. However, even with the advent of …
Studying human nociceptors: from fundamentals to clinic
Chronic pain affects one in five of the general population and is the third most important
cause of disability-adjusted life-years globally. Unfortunately, treatment remains inadequate …
cause of disability-adjusted life-years globally. Unfortunately, treatment remains inadequate …
[HTML][HTML] Human dorsal root ganglia
RV Haberberger, C Barry, N Dominguez… - Frontiers in cellular …, 2019 - frontiersin.org
Sensory neurons with cell bodies situated in dorsal root ganglia convey information from
external or internal sites of the body such as actual or potential harm, temperature or muscle …
external or internal sites of the body such as actual or potential harm, temperature or muscle …
[HTML][HTML] Deep sequencing of somatosensory neurons reveals molecular determinants of intrinsic physiological properties
Dorsal root ganglion (DRG) sensory neuron subtypes defined by their in vivo properties
display distinct intrinsic electrical properties. We used bulk RNA sequencing of genetically …
display distinct intrinsic electrical properties. We used bulk RNA sequencing of genetically …
Targeting voltage-gated calcium channels in neurological and psychiatric diseases
GW Zamponi - Nature reviews Drug discovery, 2016 - nature.com
Voltage-gated calcium channels are important regulators of brain, heart and muscle
functions, and their dysfunction can give rise to pathophysiological conditions ranging from …
functions, and their dysfunction can give rise to pathophysiological conditions ranging from …
Quantitative differences in neuronal subpopulations between mouse and human dorsal root ganglia demonstrated with RNAscope in situ hybridization
Next-generation transcriptomics in combination with imaging-based approaches have
emerged as powerful tools for the characterization of dorsal root ganglion (DRG) neuronal …
emerged as powerful tools for the characterization of dorsal root ganglion (DRG) neuronal …
[HTML][HTML] Mechanisms of osteoarthritic pain. Studies in humans and experimental models
A Eitner, GO Hofmann, HG Schaible - Frontiers in molecular …, 2017 - frontiersin.org
Pain due to osteoarthritis (OA) is one of the most frequent causes of chronic pain. However,
the mechanisms of OA pain are poorly understood. This review addresses the mechanisms …
the mechanisms of OA pain are poorly understood. This review addresses the mechanisms …