Women have more body fat than men, but in contrast to the deleterious metabolic
consequences of the central obesity typical of men, the pear-shaped body fat distribution of …

Objective: To review recent advances in understanding the role of leptin in the physiology
and pathophysiology of reproduction, with a focus on relevant clinical situations. Design: A …

Leptin is a mainly adipocyte-secreted protein that was discovered 5 years ago. Most of the
research following this discovery focused on the role of leptin in body weight regulation …

The discovery of the adipocyte-produced hormone leptin has greatly changed the field of
obesity research and our understanding of energy homeostasis. It is now accepted that …

Leptin is a hormone secreted by the adipocytes to serve as a signal to the central nervous
system to regulate energy homeostasis. Circulating leptin mainly reflects both total fat mass …

Leptin, a product of fat cells, provides a signal of nutritional status to the central nervous
system. Leptin concentrations have ultradian and diurnal fluctuations. We conducted this …

Leptin is an important regulator of body fat mass and energy expenditure during adult life.
The mechanisms by which maternal and fetal weight are regulated during pregnancy are …

Leptin is a 16-kDa cytokine secreted in humans primarily but not exclusively by adipose
tissues. Its concentration in blood is usually proportional to body fat mass, but is higher in …

Circulating concentrations of leptin are better correlated with absolute amounts of adipose
tissue [fat mass (FM)] than with relative body fatness (body mass index or percent body fat) …

Several major developments have occurred since the last edition of Handbook of Obesity:
Clinical Applications, including new clinical trials, discoveries related to drug use, and …