Purpose: Some 85% of lung cancers are smoking related. Here, we investigate the role of
serine protease HtrA3 in smoking-related lung cancer. Experimental Design: We assess …

Use of smokeless tobacco products (STPs) is associated with oral cavity cancer and other
health risks. Comprehensive analysis for chemical composition and toxicity is needed to …

Abstract The Family Smoking Prevention and Tobacco Control Act gives the US Food and
Drug Administration power to regulate tobacco products. This commentary calls for …

Smoking carcinogen nicotine-derived nitrosamine ketone (NNK) is the most potent
contributor to lung adenocarcinoma (LUAD) development, but the mechanism has not been …

Nicotine, the psychoactive ingredient in tobacco, is metabolically inactivated by CYP2A6 to
cotinine. CYP2A6 also activates procarcinogenic tobacco-specific nitrosamines (TSNA) …

Peroxisome proliferator–activated receptorPeroxisome proliferator–activated receptor
(PPAR)–α and PPARγ participate in cell proliferation and apoptosis. Few studies have …

ABSTRACT A liquid chromatography tandem mass spectrometry (LC/MS/MS) method was
developed and validated for the determination of five total tobacco‐specific N‐nitrosamines …

Quantitation of DNA adducts could provide critical information on the relationship between
exposure to tobacco smoke and cancer risk in smokers. In this study, we developed a robust …

Polycyclic aromatic hydrocarbons (PAHs), tobacco-specific nitrosamines (TSNAs) and
aromatic amines are carcinogens present in cigarette smoke. These compounds are …

5-Demethylnobiletin (5DN) is a unique citrus flavonoid with various beneficial bioactivities.
In this study, we determined the inhibitory effects of 5DN and its two major metabolites in the …