[HTML][HTML] Animal models of hepatocellular carcinoma: the role of immune system and tumor microenvironment

Z Macek Jilkova, K Kurma, T Decaens - Cancers, 2019 - mdpi.com
Hepatocellular carcinoma (HCC) is the most common type of liver cancer in adults and has
one of the highest mortality rates of solid cancers. Ninety percent of HCCs are associated …

Is the era of sorafenib over? A review of the literature

G Fan, X Wei, X Xu - Therapeutic advances in medical …, 2020 - journals.sagepub.com
Hepatocellular carcinoma (HCC) is one of the most severe diseases worldwide. For the
different stages of HCC, there are different clinical treatment strategies, such as surgical …

[HTML][HTML] Combining crocin and sorafenib improves their tumor-inhibiting effects in a rat model of diethylnitrosamine-induced cirrhotic-hepatocellular carcinoma

B Awad, AA Hamza, A Al-Maktoum, S Al-Salam, A Amin - Cancers, 2023 - mdpi.com
Simple Summary Liver cancer represents one of the most lethal forms of cancer, with
hepatocellular carcinoma (HCC) accounting for the majority of its incidences and deaths …

[HTML][HTML] DEN-induced rat model reproduces key features of human hepatocellular carcinoma

K Kurma, O Manches, F Chuffart, N Sturm… - Cancers, 2021 - mdpi.com
Simple Summary Hepatocellular carcinoma is the most frequent form of primary liver cancer,
characterized by increasing incidence and high mortality. Animal models of hepatocellular …

GNS561, a clinical-stage PPT1 inhibitor, is efficient against hepatocellular carcinoma via modulation of lysosomal functions

S Brun, E Bestion, E Raymond, F Bassissi, ZM Jilkova… - Autophagy, 2022 - Taylor & Francis
Hepatocellular carcinoma is the most frequent primary liver cancer. Macroautophagy/
autophagy inhibitors have been extensively studied in cancer but, to date, none has reached …

[HTML][HTML] In vivo and in vitro models of hepatocellular carcinoma: current strategies for translational modeling

GR Romualdo, K Leroy, CJS Costa, GB Prata… - Cancers, 2021 - mdpi.com
Simple Summary Hepatocellular carcinoma (HCC) is a highly incident and deadly malignant
neoplasia, and only a few anti-HCC drugs are currently available. Thus, the development of …

Carvacrol enhances anti-tumor activity and mitigates cardiotoxicity of sorafenib in thioacetamide-induced hepatocellular carcinoma model through inhibiting TRPM7

EH Yousef, NFA El-Magd, AM El Gayar - Life Sciences, 2023 - Elsevier
Abstract Aims Sorafenib (Sora) represents one of the few effective drugs for the treatment of
advanced hepatocellular carcinoma (HCC), while resistance and cardiotoxicity limit its …

[HTML][HTML] Targeting Akt in hepatocellular carcinoma and its tumor microenvironment

M Mroweh, G Roth, T Decaens, PN Marche… - International Journal of …, 2021 - mdpi.com
Hepatocellular carcinoma (HCC) is one of the most common causes of cancer-related
deaths worldwide, and its incidence is rising. HCC develops almost exclusively on the …

[HTML][HTML] HSP90α mediates sorafenib resistance in human hepatocellular carcinoma by necroptosis inhibition under hypoxia

Y Liao, Y Yang, D Pan, Y Ding, H Zhang, Y Ye, J Li… - Cancers, 2021 - mdpi.com
Simple Summary Hypoxia is one of the characteristics of most solid tumors and induces cell
resistant to chemotherapy. In this paper, we established a hypoxia model in both in vitro and …

[HTML][HTML] Chronic intermittent hypoxia increases cell proliferation in hepatocellular carcinoma

L Carreres, M Mercey-Ressejac, K Kurma, J Ghelfi… - Cells, 2022 - mdpi.com
Obstructive sleep apnea (OSA) syndrome is characterized by chronic intermittent hypoxia
and is associated with an increased risk of all-cause mortality, including cancer mortality …