NF-κB signaling has been discovered for nearly 40 years. Initially, NF-κB signaling was
identified as a pivotal pathway in mediating inflammatory responses. However, with …

Inflammation is a facilitating process for multiple cancer types. It is believed to affect cancer
development and progression through several etiologic pathways, including increased …

Therapy of relapsed pediatric acute lymphoblastic leukemia (ALL) is hampered by low
remission rates and high toxicity, especially in second and subsequent relapses. Our phase …

The biologic and clinical significance of KIT overexpression that associates with KIT gain-of-
function mutations occurring in subsets of acute myeloid leukemia (AML)(ie, core binding …

Immunoglobulin light chain (AL) amyloidosis is an incurable plasma cell disorder
characterized by deposition of fibrils of misfolded immunoglobulin free light chains (FLC) in …

Heparanase, the sole heparan sulfate degrading endoglycosidase, regulates multiple
biological activities that enhance tumor growth, angiogenesis and metastasis. Heparanase …

Under physiological and pathological conditions, cells activate the unfolded protein
response (UPR) to deal with the accumulation of unfolded or misfolded proteins in the …

Abstract Purpose of Review Multiple myeloma is the second most common hematologic
malignancy in the USA, with over 32,000 new cases and nearly 13,000 deaths expected in …

MicroRNAs (miRNAs) with tumor-suppressor potential might have therapeutic applications
in multiple myeloma (MM) through the modulation of still undiscovered molecular pathways …

Given the significant activity and tolerability of bendamustine, rituximab, and bortezomib in
patients with relapsed indolent and mantle cell non-Hodgkin lymphoma, and laboratory …