BACKGROUND: Microsatellite instability (MSI) status in predicting the efficacy of adjuvant
chemotherapy in colorectal cancer remains controversial. MATERIALS AND METHODS …

During the past two decades the first sequencing of the human genome was performed
showing its high degree of inter-individual differentiation, as a result of large international …

A deficient mismatch repair system (dMMR) is present in 10–20% of patients with sporadic
colorectal cancer (CRC) and is associated with a favourable prognosis in early stage …

OBJECTIVES: Colon cancers diagnosed in the interval after a complete colonoscopy may
occur due to limitations of colonoscopy or due to the development of new tumors, possibly …

Background & Aims: Colon cancers that develop after a complete colonoscopy may be the
result of “failure of colonoscopy” or rapid tumor growth. Tumors that develop via the …

Rapidly growing insights into the molecular biology of colorectal cancer (CRC) and recent
developments in gene sequencing and molecular diagnostics have led to high expectations …

Purpose Microsatellite instability (MSI), TP53 mutation, and KRAS mutation status have
been reported as prognostic factors in colon cancer. Most studies, however, have included …

Colorectal cancer (CRC) is one of the most frequent cancers in the Western world and
represents a major health burden. CRC development is a multi-step process that spans 10 …

Introduction For the past two decades, microsatellite instability (MSI) has been reported as a
robust clinical biomarker associated with survival advantage attributed to its immunogenicity …

The influence of microsatellite instability (MSI) on the prognosis of colorectal cancer (CRC)
requires more investigation. We assessed the role of MSI status in survival of individuals …